用于检测光动力疗法中单线态氧的蒽基金属有机框架的尺寸控制合成与传感特性

IF 4.3 3区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Ning Li , Ying Yang , Linshan Jia , Xiaotong Li , Yunkun Zhao , Xiaohong Hou
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引用次数: 0

摘要

开发检测单线态氧(1O2)的荧光探针对于了解 1O2 在各种器官的免疫和病理过程中的关键作用至关重要。在这项研究中,具有良好生物相容性和优异光学稳定性的尺寸可控 DPA-MOF (X) 被用作纳米探针,用于光动力疗法(PDT)中 1O2 的实时成像和监测。实验合成的 DPA-MOF (X) 可通过稀释调节粒径,并显示蓝色荧光信号。结果表明,粒径较小的 DPA-MOF (60) 对 1O2 的反应速度更快,细胞吸收能力更强。在 0-7 mM 的范围内,DPA-MOF(60)的荧光强度比(F0/Fi)与 1O2 的浓度呈线性相关,检测限为 88 μM。与大多数载流子负载传感器相比,DPA-MOF 具有一个明显的优势,即它有效地避免了荧光团从纳米材料基质中泄漏的问题,从而提高了其稳定性。此外,DPA-MOF 的可控合成有可能改善探针在肿瘤中的积累,降低人体系统的吸收率。本研究介绍了一种利用 1O2 捕获单元作为测量配体的发光金属有机框架(LMOF)传感器。该传感器具有优异的生物相容性,可用于体内或活细胞中 1O2 的高特异性和高效检测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Size-controlled synthesis and sensing properties of anthracene-based metal-organic frameworks for detection of singlet oxygen in photodynamic therapy
Developing fluorescent probes to detect singlet oxygen (1O2) is essential to understanding the critical role of 1O2 in immunological and pathological processes in various organs. In this study, size-controlled DPA-MOF (X) with good biocompatibility and excellent optical stability was used as a nanoprobe for real-time imaging and monitoring of 1O2 in photodynamic therapy (PDT). The experimentally synthesized DPA-MOF (X), which can be adjusted in particle size by dilution, exhibits blue fluorescence signals. The results show that smaller-sized DPA-MOF (60) has a faster response to 1O2 and higher cell uptake ability. The ratio of fluorescence intensity (F0/Fi) of DPA-MOF (60) showed a linear correlation with the concentration of 1O2 in the range of 0–7 mM, with a detection limit of 88 μM. DPA-MOF has a distinct advantage over most carrier loading sensors in that it effectively avoids the issue of fluorophore leakage from the nanomaterial matrix, thereby improving its stability. Additionally, the controlled synthesis of DPA-MOF can potentially improve probe accumulation in tumors and lower the uptake by the body system. This study presents a luminescent metal-organic framework (LMOF) sensor that utilizes a 1O2 capture unit as a measuring ligand. This sensor has been shown to have exceptional biocompatibility and can be utilized for highly specific and efficient detection of 1O2 in vivo or living cells.
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来源期刊
Materials Chemistry and Physics
Materials Chemistry and Physics 工程技术-材料科学:综合
CiteScore
8.70
自引率
4.30%
发文量
1515
审稿时长
69 days
期刊介绍: Materials Chemistry and Physics is devoted to short communications, full-length research papers and feature articles on interrelationships among structure, properties, processing and performance of materials. The Editors welcome manuscripts on thin films, surface and interface science, materials degradation and reliability, metallurgy, semiconductors and optoelectronic materials, fine ceramics, magnetics, superconductors, specialty polymers, nano-materials and composite materials.
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