Ning Li , Ying Yang , Linshan Jia , Xiaotong Li , Yunkun Zhao , Xiaohong Hou
{"title":"用于检测光动力疗法中单线态氧的蒽基金属有机框架的尺寸控制合成与传感特性","authors":"Ning Li , Ying Yang , Linshan Jia , Xiaotong Li , Yunkun Zhao , Xiaohong Hou","doi":"10.1016/j.matchemphys.2024.130112","DOIUrl":null,"url":null,"abstract":"<div><div>Developing fluorescent probes to detect singlet oxygen (<sup>1</sup>O<sub>2</sub>) is essential to understanding the critical role of <sup>1</sup>O<sub>2</sub> in immunological and pathological processes in various organs. In this study, size-controlled DPA-MOF (X) with good biocompatibility and excellent optical stability was used as a nanoprobe for real-time imaging and monitoring of <sup>1</sup>O<sub>2</sub> in photodynamic therapy (PDT). The experimentally synthesized DPA-MOF (X), which can be adjusted in particle size by dilution, exhibits blue fluorescence signals. The results show that smaller-sized DPA-MOF (60) has a faster response to <sup>1</sup>O<sub>2</sub> and higher cell uptake ability. The ratio of fluorescence intensity (<em>F</em><sub><em>0</em></sub>/<em>F</em><sub><em>i</em></sub>) of DPA-MOF (60) showed a linear correlation with the concentration of <sup>1</sup>O<sub>2</sub> in the range of 0–7 mM, with a detection limit of 88 μM. DPA-MOF has a distinct advantage over most carrier loading sensors in that it effectively avoids the issue of fluorophore leakage from the nanomaterial matrix, thereby improving its stability. Additionally, the controlled synthesis of DPA-MOF can potentially improve probe accumulation in tumors and lower the uptake by the body system. This study presents a luminescent metal-organic framework (LMOF) sensor that utilizes a <sup>1</sup>O<sub>2</sub> capture unit as a measuring ligand. This sensor has been shown to have exceptional biocompatibility and can be utilized for highly specific and efficient detection of <sup>1</sup>O<sub>2</sub> in vivo or living cells.</div></div>","PeriodicalId":18227,"journal":{"name":"Materials Chemistry and Physics","volume":"329 ","pages":"Article 130112"},"PeriodicalIF":4.3000,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Size-controlled synthesis and sensing properties of anthracene-based metal-organic frameworks for detection of singlet oxygen in photodynamic therapy\",\"authors\":\"Ning Li , Ying Yang , Linshan Jia , Xiaotong Li , Yunkun Zhao , Xiaohong Hou\",\"doi\":\"10.1016/j.matchemphys.2024.130112\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Developing fluorescent probes to detect singlet oxygen (<sup>1</sup>O<sub>2</sub>) is essential to understanding the critical role of <sup>1</sup>O<sub>2</sub> in immunological and pathological processes in various organs. In this study, size-controlled DPA-MOF (X) with good biocompatibility and excellent optical stability was used as a nanoprobe for real-time imaging and monitoring of <sup>1</sup>O<sub>2</sub> in photodynamic therapy (PDT). The experimentally synthesized DPA-MOF (X), which can be adjusted in particle size by dilution, exhibits blue fluorescence signals. The results show that smaller-sized DPA-MOF (60) has a faster response to <sup>1</sup>O<sub>2</sub> and higher cell uptake ability. The ratio of fluorescence intensity (<em>F</em><sub><em>0</em></sub>/<em>F</em><sub><em>i</em></sub>) of DPA-MOF (60) showed a linear correlation with the concentration of <sup>1</sup>O<sub>2</sub> in the range of 0–7 mM, with a detection limit of 88 μM. DPA-MOF has a distinct advantage over most carrier loading sensors in that it effectively avoids the issue of fluorophore leakage from the nanomaterial matrix, thereby improving its stability. Additionally, the controlled synthesis of DPA-MOF can potentially improve probe accumulation in tumors and lower the uptake by the body system. This study presents a luminescent metal-organic framework (LMOF) sensor that utilizes a <sup>1</sup>O<sub>2</sub> capture unit as a measuring ligand. This sensor has been shown to have exceptional biocompatibility and can be utilized for highly specific and efficient detection of <sup>1</sup>O<sub>2</sub> in vivo or living cells.</div></div>\",\"PeriodicalId\":18227,\"journal\":{\"name\":\"Materials Chemistry and Physics\",\"volume\":\"329 \",\"pages\":\"Article 130112\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-10-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materials Chemistry and Physics\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0254058424012409\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Chemistry and Physics","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0254058424012409","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Size-controlled synthesis and sensing properties of anthracene-based metal-organic frameworks for detection of singlet oxygen in photodynamic therapy
Developing fluorescent probes to detect singlet oxygen (1O2) is essential to understanding the critical role of 1O2 in immunological and pathological processes in various organs. In this study, size-controlled DPA-MOF (X) with good biocompatibility and excellent optical stability was used as a nanoprobe for real-time imaging and monitoring of 1O2 in photodynamic therapy (PDT). The experimentally synthesized DPA-MOF (X), which can be adjusted in particle size by dilution, exhibits blue fluorescence signals. The results show that smaller-sized DPA-MOF (60) has a faster response to 1O2 and higher cell uptake ability. The ratio of fluorescence intensity (F0/Fi) of DPA-MOF (60) showed a linear correlation with the concentration of 1O2 in the range of 0–7 mM, with a detection limit of 88 μM. DPA-MOF has a distinct advantage over most carrier loading sensors in that it effectively avoids the issue of fluorophore leakage from the nanomaterial matrix, thereby improving its stability. Additionally, the controlled synthesis of DPA-MOF can potentially improve probe accumulation in tumors and lower the uptake by the body system. This study presents a luminescent metal-organic framework (LMOF) sensor that utilizes a 1O2 capture unit as a measuring ligand. This sensor has been shown to have exceptional biocompatibility and can be utilized for highly specific and efficient detection of 1O2 in vivo or living cells.
期刊介绍:
Materials Chemistry and Physics is devoted to short communications, full-length research papers and feature articles on interrelationships among structure, properties, processing and performance of materials. The Editors welcome manuscripts on thin films, surface and interface science, materials degradation and reliability, metallurgy, semiconductors and optoelectronic materials, fine ceramics, magnetics, superconductors, specialty polymers, nano-materials and composite materials.