胫骨粘菌病：一个尚未解决的实体病例报告

Q2 Medicine

Journal of Clinical Orthopaedics and Trauma Pub Date : 2024-11-01 DOI:10.1016/j.jcot.2024.102793

Lavindra Tomar, Gaurav Govil

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引用次数: 0

摘要

胫骨黏菌病是一种侵袭性极强的真菌感染。胫骨黏菌病是一种侵袭性极强的真菌感染，并不常见，尤其是在免疫力低下的宿主中，他们更容易患上这种疾病。一名 45 岁男性的左腿溃疡不愈合，免疫力低下的宿主出现了胫骨远端下四分之三处的放射性溶解性病变。初次活检证实为结核性病变，服用抗结核药物后放射学病灶愈合。然而，再次活检显示为粘孢子菌病，抗真菌药物仍然无效，伤口愈合无反应，持续化脓。胫骨真菌感染仍是一个尚未解决的问题，其临床和功能预后较差。早期发现、高度怀疑并使用足量的抗真菌药物可解决这一可怕的感染问题，但有效的治疗方法仍是一个未解之谜。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mucor mycosis of tibia: A case report of An unsolved entity

Mucormycosis of tibia is a highly aggressive fungal infection. It is an uncommon affection especially in immunocompromised host who have more propensity for such affections.

The nonhealing ulcer of the left leg in an immunocompromised host status of a 45-year-old male presented with a radiological lytic lesion of the distal lower fourth of tibia. The initial biopsy confirmed tubercular affection which responded to antitubercular medications to allow radiological healing. However, the repeat biopsy showed Mucormycosis which remained recalcitrant to antifungal medications with unresponsive wound healing and persisting suppuration. The case presented unique scenario of superadded fungal infection in a healing tubercular osteomyelitis tibia with alcoholic liver disease compromised host immunity.

The fungal infection of tibia remains an unsolved entity with poor clinical and functional outcomes. An early detection, high degree of suspicion with an adequate dosage of antifungal medications may allow resolution of the dreaded infection though an effective treatment remains an unsolved entity.

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来源期刊

Journal of Clinical Orthopaedics and Trauma Medicine-Orthopedics and Sports Medicine

CiteScore

4.30

自引率

0.00%

发文量

181

审稿时长

92 days

期刊介绍： Journal of Clinical Orthopaedics and Trauma (JCOT) aims to provide its readers with the latest clinical and basic research, and informed opinions that shape today''s orthopedic practice, thereby providing an opportunity to practice evidence-based medicine. With contributions from leading clinicians and researchers around the world, we aim to be the premier journal providing an international perspective advancing knowledge of the musculoskeletal system. JCOT publishes content of value to both general orthopedic practitioners and specialists on all aspects of musculoskeletal research, diagnoses, and treatment. We accept following types of articles: • Original articles focusing on current clinical issues. • Review articles with learning value for professionals as well as students. • Research articles providing the latest in basic biological or engineering research on musculoskeletal diseases. • Regular columns by experts discussing issues affecting the field of orthopedics. • "Symposia" devoted to a single topic offering the general reader an overview of a field, but providing the specialist current in-depth information. • Video of any orthopedic surgery which is innovative and adds to present concepts. • Articles emphasizing or demonstrating a new clinical sign in the art of patient examination is also considered for publication. Contributions from anywhere in the world are welcome and considered on their merits.