利妥昔单抗在原发性膜性肾病治疗中的不同剂量方案:系统综述。

IF 2.1 Q2 UROLOGY & NEPHROLOGY
Yi Yu, Ricong Xu, Zhijian Li, Qijun Wan
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引用次数: 0

摘要

原发性膜性肾病(PMN)是成人原发性肾病综合征的主要病理类型之一。以磷脂酶 A2 受体(PLA2R)等荚膜细胞抗原为靶点的致病性自身抗体导致该病。患者在接受常规免疫抑制疗法治疗时经常会出现明显的不良反应。利妥昔单抗(RTX)是一种小鼠/人类单克隆抗体,可选择性地消耗 B 细胞,导致血液循环中的抗体水平下降,从而有助于缓解膜性肾病。在全球范围内,各种 RTX 剂量方案已被用于治疗膜性肾病,并取得了令人满意的效果。然而,RTX的最佳剂量仍有待确定。本文回顾了迄今为止不同剂量 RTX 在 PMN 治疗中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Different Dosage Regimens of Rituximab in Primary Membranous Nephropathy Treatment: A Systematic Review.

Primary membranous nephropathy (PMN) is one of the prevalent pathological types of adult primary nephrotic syndrome. Pathogenic autoantibodies targeting podocyte antigens such as phospholipase A2 receptor (PLA2R) lead to the disease. Patients frequently experience notable adverse effects when treated with conventional immunosuppressive therapies. Rituximab (RTX), a mouse/human monoclonal antibody, selectively depletes B cells and leads to a decrease in the antibody levels in the circulation, which helps to alleviate membranous nephropathy. Various RTX dosage regimens have been applied globally in the PMN treatment with satisfactory effects. Nevertheless, the optimal dosage of RTX has yet to be determined. This article reviews the application of different doses of RTX in the management of PMN so far.

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来源期刊
CiteScore
3.90
自引率
5.00%
发文量
40
审稿时长
16 weeks
期刊介绍: International Journal of Nephrology and Renovascular Disease is an international, peer-reviewed, open-access journal focusing on the pathophysiology of the kidney and vascular supply. Epidemiology, screening, diagnosis, and treatment interventions are covered as well as basic science, biochemical and immunological studies. In particular, emphasis will be given to: -Chronic kidney disease- Complications of renovascular disease- Imaging techniques- Renal hypertension- Renal cancer- Treatment including pharmacological and transplantation- Dialysis and treatment of complications of dialysis and renal disease- Quality of Life- Patient satisfaction and preference- Health economic evaluations. The journal welcomes submitted papers covering original research, basic science, clinical studies, reviews & evaluations, guidelines, expert opinion and commentary, case reports and extended reports. The main focus of the journal will be to publish research and clinical results in humans but preclinical, animal and in vitro studies will be published where they shed light on disease processes and potential new therapies and interventions.
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