与阿尔茨海默病相关的轻度认知障碍和轻度痴呆症患者的生活质量：系统回顾

IF 3.9 3区医学 Q1 CLINICAL NEUROLOGY

Neurology and Therapy Pub Date : 2024-11-03 DOI:10.1007/s40120-024-00676-9

Joanna Campbell, Louis Lavoie, Mariana Farraia, Rachel Huelin, Quanwu Zhang, Amir Abbas Tahami Monfared

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引用次数: 0

摘要

轻度认知障碍（MCI）和阿尔茨海默病（AD）对患者的生活质量（QoL）有着深远的影响，随着病情的发展，患者的生活质量会逐渐下降。本系统性综述旨在总结已发表的有关患者报告结果（PROs）的证据，研究对象包括因 AD 引起的 MCI 患者和轻度 AD 痴呆患者。我们在五个主要数据库中进行了全面检索，以确定对这些患者群体的效用值、不效用和 QoL 测量进行报告的研究。共有 23 项研究采用了各种 QoL 评估工具，包括 EQ-5D（14 项）、SF-36/SF-12（4 项）和 QOL-AD （11 项）。据报告，MCI 患者的 EQ-5D 得分从 0.81 到 0.92 不等，轻度 AD 患者的 EQ-5D 得分从 0.67 到 0.85 不等，这表明随着病情的发展，患者的 QoL 明显下降。MCI患者的QOL-AD评分从33.8分到42.5分不等，轻度AD患者的QOL-AD评分从32.4分到38.1分不等，这同样反映出随着病情的发展，患者的QoL会受到更大的损害。与安慰剂相比，干预措施通常会使PROs的下降幅度较小，这表明治疗对缓解QoL恶化有积极影响。研究结果强调了 MCI 和轻度 AD 在 QoL 方面的显著差异，强调了早期干预对保护 QoL 和延缓疾病进展的潜在益处。本综述强调了继续开展研究以更好地了解 MCI 和轻度 AD 痴呆症患者 QoL 的重要性，尤其是在获取全面的患者报告结果和评估长期干预效果方面。这些发现有助于在临床实践中采用更明智的方法，并为早期 AD 的管理决策提供支持。

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Quality of Life in Mild Cognitive Impairment and Mild Dementia Associated with Alzheimer's Disease: A Systematic Review.

Mild cognitive impairment (MCI) and Alzheimer's disease (AD) have a profound impact on patients' quality of life (QoL), with progressive declines occurring as the disease advances. This systematic review aims to summarize the published evidence on patient-reported outcomes (PROs) in individuals with MCI due to AD and mild AD dementia. Comprehensive searches were conducted across five major databases to identify studies reporting on utility values, disutilities, and QoL measures in these patient populations. A total of 23 studies were included that utilized various QoL assessment tools, including EQ-5D (n = 14), SF-36/SF-12 (n = 4), and QOL-AD (n = 11). Reported EQ-5D scores ranged from 0.81 to 0.92 for patients with MCI and from 0.67 to 0.85 for those with mild AD, indicating a noticeable decline in QoL as the disease progresses. QOL-AD scores ranged from 33.8 to 42.5 for MCI and from 32.4 to 38.1 for mild AD, equally reflecting the greater impairment in QoL with disease advancement. Interventions were generally associated with smaller declines in PROs compared to placebo, suggesting a positive impact of treatment in mitigating QoL deterioration. The findings underscore the significant QoL differences between MCI and mild AD, emphasizing the potential benefit of early intervention to preserve QoL and delay disease progression. This review highlights the importance of continued research to better understand QoL in patients with MCI and mild AD dementia, particularly in terms of capturing comprehensive patient-reported outcomes and evaluating the effectiveness of interventions over time. These findings can contribute to a more informed approach in clinical practice and support decision-making in the management of early-stage AD.

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来源期刊

Neurology and Therapy CLINICAL NEUROLOGY-

CiteScore

5.40

自引率

8.10%

发文量

103

审稿时长

6 weeks

期刊介绍： Aims and Scope Neurology and Therapy aims to provide reliable and inclusive, rapid publication for all therapy related research for neurological indications, supporting the timely dissemination of research with a global reach, to help advance scientific discovery and support clinical practice. Neurology and Therapy is an international, open access, peer reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world and health outcomes research around the discovery, development, and use of neurological and psychiatric therapies, (also covering surgery and devices). Studies relating to diagnosis, pharmacoeconomics, public health, quality of life, and patient care, management, and education are also welcomed. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, case reports, trial designs, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Neurology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research. Rapid Publication The journal’s rapid publication timelines aim for a peer review decision within 2 weeks of submission. If an article is accepted, it will be published online 3-4 weeks from acceptance. These rapid timelines are achieved through the combination of a dedicated in-house editorial team, who closely manage article workflow, and an extensive Editorial and Advisory Board who assist with rapid peer review. 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