中国采用胱抑素 C 检测的挑战与前景：实验室技术人员的视角。

IF 2.5 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinical biochemistry Pub Date : 2024-11-01 DOI:10.1016/j.clinbiochem.2024.110839

Xiaerbanu Nizhamuding , Yang Liu , Jie Zeng , Haijian Zhao , Tianjiao Zhang , Chuanbao Zhang

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引用次数: 0

摘要

胱抑素 C（CysC）属于半胱氨酸蛋白酶抑制剂超家族，由体内所有有核细胞产生，其含量非常稳定，不受年龄、性别、饮食和肌肉质量的影响。与评估肾小球滤过率（GFR）的传统生物标记物（如肌酐）相比，CysC 被认为是评估肾小球滤过率（GFR）的理想生物标记物。然而，临床医生并没有充分利用 CysC 来评估肾小球滤过率，这可能是由于临床医生对 CysC 的认识不足或缺乏标准化的定量方法等各种原因造成的。本综述从实验室技术人员的角度对上述问题进行了讨论和分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Challenges and Perspectives on the Adoption of Cystatin C testing in China: A laboratory technician’s perspective

Cystatin C (CysC) belongs to the cysteine protease inhibitor superfamily and is produced by all nucleated cells in the body in very stable amounts independent of age, sex, diet, and muscle mass. CysC is considered an ideal biomarker for assessing glomerular filtration rate (GFR) compared to traditional biomarkers for assessing GFR, such as creatinine. However, CysC is not sufficiently utilized for GFR assessment by clinicians, probably for various reasons such as insufficient understanding among clinicians or a lack of standardized quantitative methods. This review discusses and analyzes the aforementioned issues from the perspective of laboratory technicians.

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来源期刊

Clinical biochemistry 医学-医学实验技术

CiteScore

5.10

自引率

0.00%

发文量

151

审稿时长

25 days

期刊介绍： Clinical Biochemistry publishes articles relating to clinical chemistry, molecular biology and genetics, therapeutic drug monitoring and toxicology, laboratory immunology and laboratory medicine in general, with the focus on analytical and clinical investigation of laboratory tests in humans used for diagnosis, prognosis, treatment and therapy, and monitoring of disease.