细胞外囊泡和脂蛋白的治疗和药理应用。

IF 6.8 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Krisztina Németh, Brachyahu M. Kestecher, Sayam Ghosal, Bernadett R. Bodnár, Ágnes Kittel, Szabolcs Hambalkó, Csenger Kovácsházi, Zoltán Giricz, Péter Ferdinandy, Xabier Osteikoetxea, Ralph Burkhardt, Edit I. Buzas, Evelyn Orsó
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引用次数: 0

摘要

近年来,人们采取了各种方法来消除与细胞外囊泡共分离的脂蛋白,因为脂蛋白最初被视为污染实体。然而,新的发现正在重塑我们的观点。在体液中,这些不同的颗粒不仅共存,而且它们之间还可能发生相互作用。细胞外囊泡和脂蛋白可以相互关联、共享货物、影响彼此的功能,并在疾病的病理机制中共同发挥作用。此外,它们之间的关联对降脂策略的治疗和药理方面也有重要影响。细胞外囊泡和脂蛋白颗粒可能在从血液循环中相互清除对方的过程中发挥作用。本小节旨在深入探讨这些方面。在这里,我们表明,在某些生理和病理条件下,细胞外囊泡和脂蛋白是 "伙伴",而不是 "陌生人 "或 "对手"。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Therapeutic and pharmacological applications of extracellular vesicles and lipoproteins

Therapeutic and pharmacological applications of extracellular vesicles and lipoproteins

In recent years, various approaches have been undertaken to eliminate lipoproteins co-isolated with extracellular vesicles, as they were initially regarded as contaminating entities. However, novel discoveries are reshaping our perspective. In body fluids, these distinct particles not only co-exist, but also interactions between them are likely to occur. Extracellular vesicles and lipoproteins can associate with each other, share cargo, influence each other's functions, and jointly have a role in the pathomechanisms of diseases. Additionally, their association carries important implications for therapeutic and pharmacological aspects of lipid-lowering strategies. Extracellular vesicles and lipoprotein particles may have roles in the elimination of each other from the circulation. The objective of this minireview is to delve into these aspects. Here, we show that under certain physiological and pathological conditions, extracellular vesicles and lipoproteins are ‘partners’ rather than ‘strangers’ or ‘rivals’.

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来源期刊
CiteScore
15.40
自引率
12.30%
发文量
270
审稿时长
2.0 months
期刊介绍: The British Journal of Pharmacology (BJP) is a biomedical science journal offering comprehensive international coverage of experimental and translational pharmacology. It publishes original research, authoritative reviews, mini reviews, systematic reviews, meta-analyses, databases, letters to the Editor, and commentaries. Review articles, databases, systematic reviews, and meta-analyses are typically commissioned, but unsolicited contributions are also considered, either as standalone papers or part of themed issues. In addition to basic science research, BJP features translational pharmacology research, including proof-of-concept and early mechanistic studies in humans. While it generally does not publish first-in-man phase I studies or phase IIb, III, or IV studies, exceptions may be made under certain circumstances, particularly if results are combined with preclinical studies.
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