MUC1 在泌尿生殖系统癌症中的研究进展。

IF 9.2 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cellular & Molecular Biology Letters Pub Date : 2024-11-03 DOI:10.1186/s11658-024-00654-x

Weipu Mao, Houliang Zhang, Keyi Wang, Jiang Geng, Jianping Wu

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引用次数: 0

摘要

MUC1 是一种高分子量的高度糖基化跨膜蛋白。它在润滑和保护粘膜上皮、参与上皮细胞更新和分化、调节细胞粘附、信号转导和免疫反应等方面发挥作用。MUC1 在正常和恶性上皮细胞中均有表达，在多种肿瘤的诊断、预后预测和临床监测中发挥着重要作用，有望成为新的治疗靶点。本文综述了MUC1的结构特点、表达调控机制、在泌尿生殖系统癌症发生发展中的研究进展及其临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Research progress of MUC1 in genitourinary cancers.

MUC1 is a highly glycosylated transmembrane protein with a high molecular weight. It plays a role in lubricating and protecting mucosal epithelium, participates in epithelial cell renewal and differentiation, and regulates cell adhesion, signal transduction, and immune response. MUC1 is expressed in both normal and malignant epithelial cells, and plays an important role in the diagnosis, prognosis prediction and clinical monitoring of a variety of tumors and is expected to be a new therapeutic target. This article reviews the structural features, expression regulation mechanism, and research progress of MUC1 in the development of genitourinary cancers and its clinical applications.

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来源期刊

Cellular & Molecular Biology Letters 生物-生化与分子生物学

CiteScore

11.60

自引率

13.30%

发文量

101

审稿时长

3 months

期刊介绍： Cellular & Molecular Biology Letters is an international journal dedicated to the dissemination of fundamental knowledge in all areas of cellular and molecular biology, cancer cell biology, and certain aspects of biochemistry, biophysics and biotechnology.