Zacharias Chalampalakis, Markus Ortner, Masar Almuttairi, Martin Bauer, Ernesto Gomez Tamm, Albrecht Ingo Schmidt, Barbara Katharina Geist, Marcus Hacker, Oliver Langer, Roberta Frass-Kriegl, Ivo Rausch
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Anatomical MR images were used post PET reconstruction for partial volume correction of the input function measurements.</p><p><strong>Results: </strong>Reconstruction of dynamic PET data with motion-compensation provided nearly motion-free series of PET frame data, suitable for image derived input function measurements of the portal vein. After partial volume correction, the individual input function measurements were within a 16.1% error range from the true activity in the portal vein compartment at the time of PET acquisition.</p><p><strong>Conclusion: </strong>The proposed protocol demonstrates clinically feasible PET/MR imaging of the liver for pharmacokinetic studies with accurate quantification of the portal vein input function, including correction for respiratory motion and partial volume effects.</p>","PeriodicalId":11559,"journal":{"name":"EJNMMI Physics","volume":"11 1","pages":"90"},"PeriodicalIF":3.0000,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11532313/pdf/","citationCount":"0","resultStr":"{\"title\":\"Development of quantitative PET/MR imaging for measurements of hepatic portal vein input function: a phantom study.\",\"authors\":\"Zacharias Chalampalakis, Markus Ortner, Masar Almuttairi, Martin Bauer, Ernesto Gomez Tamm, Albrecht Ingo Schmidt, Barbara Katharina Geist, Marcus Hacker, Oliver Langer, Roberta Frass-Kriegl, Ivo Rausch\",\"doi\":\"10.1186/s40658-024-00694-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Accurate pharmacokinetic modelling in PET necessitates measurements of an input function, which ideally is acquired non-invasively from image data. 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引用次数: 0
摘要
背景：PET 药物动力学模型的准确建立需要对输入函数进行测量，而输入函数最好是从图像数据中非侵入性获取的。肝药代动力学建模需要考虑两个输入函数，以考虑肝动脉和门静脉的血液供应。由于门静脉较小，且呼吸运动会造成图像伪影，因此门静脉的图像衍生测量具有挑战性。在这项工作中，我们试图利用模型实验来证明专用 PET/MR 方案如何应对这些挑战，并有可能在临床设置中提供门静脉的输入功能测量：方法：定制三维打印 PET/MR 模型，模拟肝脏和门静脉。PET/MR 采集是在模拟呼吸运动的情况下进行的。PET/MR 成像方案包括门静脉的高分辨率解剖 MR 成像，然后在专用运动跟踪 MR 序列的同时进行 PET 采集。从 PET 数据中提取运动跟踪和变形信息，然后用于 PET 重建，以生成无运动的动态系列 PET 图像。PET 重建后的解剖 MR 图像用于输入功能测量的部分容积校正：结果：利用运动补偿重建动态 PET 数据可提供几乎无运动的 PET 帧数据系列，适用于门静脉的图像导出输入功能测量。经过部分容积校正后，单个输入功能测量值与 PET 采集时门静脉区真实活动的误差范围在 16.1% 以内：结论：所提出的方案证明了用于药物动力学研究的肝脏 PET/MR 成像在临床上是可行的，能准确量化门静脉输入功能，包括校正呼吸运动和部分容积效应。
Development of quantitative PET/MR imaging for measurements of hepatic portal vein input function: a phantom study.
Background: Accurate pharmacokinetic modelling in PET necessitates measurements of an input function, which ideally is acquired non-invasively from image data. For hepatic pharmacokinetic modelling two input functions need to be considered, to account for the blood supply from the hepatic artery and portal vein. Image-derived measurements at the portal vein are challenging due to its small size and image artifacts caused by respiratory motion. In this work we seek to demonstrate, using phantom experiments, how a dedicated PET/MR protocol can tackle these challenges and potentially provide input function measurements of the portal vein in a clinical setup.
Methods: A custom 3D printed PET/MR phantom was constructed to mimic the liver and portal vein. PET/MR acquisitions were made with emulated respiratory motion. The PET/MR imaging protocol consisted of high-resolution anatomical MR imaging of the portal vein, followed by a PET acquisition in parallel to a dedicated motion-tracking MR sequence. Motion tracking and deformation information were extracted from PET data and subsequently used in PET reconstruction to produce dynamic series of motion-free PET images. Anatomical MR images were used post PET reconstruction for partial volume correction of the input function measurements.
Results: Reconstruction of dynamic PET data with motion-compensation provided nearly motion-free series of PET frame data, suitable for image derived input function measurements of the portal vein. After partial volume correction, the individual input function measurements were within a 16.1% error range from the true activity in the portal vein compartment at the time of PET acquisition.
Conclusion: The proposed protocol demonstrates clinically feasible PET/MR imaging of the liver for pharmacokinetic studies with accurate quantification of the portal vein input function, including correction for respiratory motion and partial volume effects.
期刊介绍：
EJNMMI Physics is an international platform for scientists, users and adopters of nuclear medicine with a particular interest in physics matters. As a companion journal to the European Journal of Nuclear Medicine and Molecular Imaging, this journal has a multi-disciplinary approach and welcomes original materials and studies with a focus on applied physics and mathematics as well as imaging systems engineering and prototyping in nuclear medicine. This includes physics-driven approaches or algorithms supported by physics that foster early clinical adoption of nuclear medicine imaging and therapy.
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