维生素 D 激活 apelin/APJ 系统可减轻与年龄有关的肌肉萎缩。

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2024-10-31 DOI:10.1016/j.lfs.2024.123205

Yoo Jeong Lee, Gyu Hee Kim, Da Som Lee, Hyeon-Ju Jeong, Joo Hyun Lim

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引用次数: 0

摘要

目的：与年龄有关的虚弱和体力活动的减少会导致肌肉质量、功能和力量的退化性丧失，这就是所谓的肌肉疏松症。越来越多的证据表明，维生素 D 对肌肉健康有益。然而，维生素 D 的分子机制尚未完全阐明。在这项研究中，我们旨在证明维生素 D 是否能克服因衰老导致的肌肉萎缩，尤其是在肌动蛋白的调节方面：主要方法：将幼年（3 个月大）和老年（18 个月大）C57BL/6 小鼠分为以下 3 组：正常饮食（1000 IU/kg）、维生素 D3 补充饮食（20,000 IU/kg）和正常饮食加运动 4 个月：主要研究结果：我们发现，补充维生素 D3 可逆转因衰老导致的肌肉力量和质量下降。维生素 D3 能显著降低老龄小鼠肌肉中肌肉萎缩和细胞衰老相关标志物的水平。有趣的是，我们观察到，在补充维生素 D3 的饮食中，老年肌肉中凋亡素及其受体（APJ）的表达明显增加，而在年轻小鼠中则没有增加。此外，循环中的白细胞介素-6（IL-6）和生长分化因子 8（GDF8）水平在老年小鼠中明显升高，但在维生素 D3 治疗后得到恢复：我们目前的数据表明，补充维生素 D3 可改善衰老引起的肌肉萎缩和衰老，与运动的效果类似，这表明维生素 D 作为一种干预策略对预防衰老引起的代谢性疾病具有积极影响。

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Activation of the apelin/APJ system by vitamin D attenuates age-related muscle atrophy

Aims

Age-related frailty and reduced physical activity contribute to a degenerative loss of muscle mass, function, and strength, which is known as sarcopenia. Increasing evidence has shown that vitamin D has beneficial effects on the muscle health. However, the molecular mechanisms of vitamin D have not been fully elucidated. In this study, we aimed to demonstrate whether vitamin D can overcome muscle atrophy due to aging, especially with respect to the regulation of myokines.

Main methods

Young (3-month-old) and aged (18-month-old) C57BL/6 mice were assigned to the following 3 groups: normal diet (1000 IU/kg), vitamin D₃-supplemented diet (20,000 IU/kg), and normal diet plus exercise for 4 months.

Key findings

We found that the reduction in muscle strength and mass due to aging was reversed by vitamin D₃ supplementation. The levels of markers involved in muscle atrophy and cellular senescence in the muscle of the aged mice were substantially decreased by vitamin D₃. Interestingly, we observed that the expression of apelin and its receptor (APJ), which is known to be secreted after exercise, significantly increased in aged muscles with a vitamin D₃-supplemented diet but not in the young mice. Moreover, circulating interleukin-6 (IL-6) and growth differentiation factor 8 (GDF8) levels were significantly increased in the aged mice but were restored by vitamin D₃ treatment.

Significance

Our present data indicate that vitamin D₃ supplementation ameliorates aging-induced muscle atrophy and senescence, similar to the effects of exercise, suggesting the positive impact of vitamin D as an intervention strategy to prevent aging-induced metabolic diseases.

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.