了解神经变性机制的类器官模型方法：全面回顾。

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2024-10-30 DOI:10.1016/j.lfs.2024.123198

Hanieh Jalali , Sana Rahimian , Nasim Shahsavarian , Rozhan Norouzi , Zahra Ahmadiyeh , Hossein Najafi , Hasti Golchin

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引用次数: 0

摘要

神经退行性疾病（NDs）是神经系统的严重疾病，其病因至今仍未完全明了。由于传统的体外模型和动物模型往往不能准确再现在人类身上观察到的疾病表型，因此建立神经退行性疾病的复杂病理机制模型长期以来一直是一个巨大的挑战；然而，类器官技术的兴起为开发创新疾病模型开辟了新的途径，可以更好地捕捉人类神经系统的细微差别。类器官平台有望促进未来临床试验的设计，增进我们对这些破坏性神经疾病的了解，并加快发现有效的个性化疗法。这篇综合综述讨论了神经类器官技术的最新进展，探讨了患者来源的类器官在模拟 NDs 病症方面的潜力，并介绍了与其发展或进展机制相关的研究结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The organoid modeling approach to understanding the mechanisms underlying neurodegeneration: A comprehensive review

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The organoid modeling approach to understanding the mechanisms underlying neurodegeneration: A comprehensive review

Neurodegenerative diseases (NDs) are severe disorders of the nervous system, and their causes are still not completely understood. Modeling the complex pathological mechanisms underlying NDs has long posed a significant challenge, as traditional in vitro and animal models often fail to accurately recapitulate the disease phenotypes observed in humans; however, the rise of organoid technology has opened new approaches for developing innovative disease models that can better capture the nuances of the human nervous system. Organoid platforms hold promise for contributing to the design of future clinical trials and advancing our understanding of these devastating neurological conditions and accelerate the discovery of effective, personalized therapies. This comprehensive review discusses the recent advancements in neural organoid technology and explores the potential of patient-derived organoids for modeling NDs conditions and presents findings related to the mechanisms of their development or progress.

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.