ORIENT 饮食：中国脑卒中高危人群的潜在神经保护膳食模式。

IF 4.2 2区医学 Q2 GERIATRICS & GERONTOLOGY

Journal of the American Medical Directors Association Pub Date : 2024-10-30 DOI:10.1016/j.jamda.2024.105331

Luowei Chen PhD , Wansi Zhong MD , Hui Chen PhD , Ying Zhou PhD , Wang Ran MD , Yaode He MD , Tingxia Zhang MD , Xiao Zhu MD , Xin Xu PhD , Changzheng Yuan ScD, MSc, BM , Min Lou MD, PhD

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引用次数: 0

摘要

目的：鉴于亚洲文化和饮食习惯的特殊性，有必要专门为亚洲中风高危人群建立神经保护性饮食模式，以预防认知障碍：鉴于亚洲文化和饮食习惯的特殊性，有必要专门为亚洲中风高危人群建立神经保护性饮食模式，以预防认知障碍：设计：系统回顾和横断面研究：环境和参与者：CIRCLE（NCT03542734）研究中的中国中风高危人群：方法：根据对认知-饮食领域的亚洲研究进行的系统回顾，将地中海-DASH饮食干预神经退行性延迟（MIND）饮食中的西方食物替换为适当的亚洲食物，并改进推荐的摄入频率，从而开发出东方干预增强神经认知愈合（ORIENT）饮食。根据美国国立神经疾病与中风研究所和加拿大中风网络的血管认知障碍电池，认知障碍的定义是总体认知得分低于样本平均值≥1 SD：最终共纳入 568 名参与者，其中男性 325 人（57.2%），平均年龄为 60.5 ± 7.3 岁。在对人口统计学变量、生活方式因素和健康状况进行调整后，ORIENT得分最高三等分的参与者发生认知障碍的几率比最低三等分的参与者低60.5%（几率比=0.395，95% CI=0.165-0.944，P=0.044）。多元线性回归分析显示，ORIENT得分每增加1分，全局认知得分就会增加0.048分，迷你精神状态检查得分增加0.281分，蒙特利尔认知评估得分增加0.344分：结论与启示：ORIENT饮食的高依从性与认知障碍发生几率的降低相关，为中国脑卒中高危人群提供了一种潜在的神经保护饮食模式。

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ORIENT Diet: A Potential Neuroprotective Dietary Pattern for Chinese Stroke High-Risk Population

Objectives

Given the particularity of Asian cultures and dietary habits, there is a need to establish a neuroprotective dietary pattern specially for the Asian stroke high-risk population, to prevent cognitive impairment.

Design

A systematic review and cross-sectional study.

Setting and Participants

Chinese stroke high-risk population from the CIRCLE (NCT03542734) study.

Methods

The Oriental Intervention for Enhanced Neurocognitive healTh (ORIENT) diet was developed by replacing the western foods in the Mediterranean-DASH diet Intervention for Neurodegenerative Delay (MIND) diet with appropriate Asian alternatives, and refining the recommended intake frequency based on a systematic review, which examined Asian studies in the cognition-diet field. Cognitive impairment was defined as a global cognitive score ≥1 SD below the sample mean, based on the National Institute of Neurological Disorders and Stroke and Canadian Stroke Network vascular cognitive impairment battery.

Results

A total of 568 participants were finally included, with 325 men (57.2%) and a mean age of 60.5 ± 7.3 years. Participants in the highest tertile of ORIENT score had 60.5% lower odds of cognitive impairment than those in the lowest tertile (odds ratio = 0.395, 95% CI = 0.165-0.944, P = .044) when adjusted for demographic variables, lifestyle factors, and health status. Multiple linear regression analysis showed that each 1-point increase in ORIENT score was associated with 0.048 higher global cognitive score, 0.281 higher Mini-Mental State Examination score, and 0.344 higher Montreal Cognitive Assessment score.

Conclusions and Implications

High adherence to ORIENT diet was associated with lower odds of cognitive impairment, providing a potential neuroprotective dietary pattern for Chinese stroke high-risk population.

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来源期刊

Journal of the American Medical Directors Association 医学-老年医学

CiteScore

11.10

自引率

6.60%

发文量

472

审稿时长

44 days

期刊介绍： JAMDA, the official journal of AMDA - The Society for Post-Acute and Long-Term Care Medicine, is a leading peer-reviewed publication that offers practical information and research geared towards healthcare professionals in the post-acute and long-term care fields. It is also a valuable resource for policy-makers, organizational leaders, educators, and advocates. The journal provides essential information for various healthcare professionals such as medical directors, attending physicians, nurses, consultant pharmacists, geriatric psychiatrists, nurse practitioners, physician assistants, physical and occupational therapists, social workers, and others involved in providing, overseeing, and promoting quality