二尖瓣手术中心房颤动手术消融病灶设置的长期影响:多中心倾向分数加权研究。

IF 4.9 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Won Kyung Pyo, Joon Bum Kim, Yang Hyun Cho, Hyung Gon Je, Hee-Jung Kim, Seung Hyun Lee
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引用次数: 0

摘要

目的本研究旨在评估心房颤动(房颤)手术消融(SA)的病灶组对长期预后的影响,并确定最佳病灶组:2005 年至 2017 年间,参与研究的机构共有 1825 名患者在接受二尖瓣手术的同时接受了房颤消融术。其中,529 名患者接受了左心房(LA)消融术,其余患者接受了双心房(BA)消融术。将死亡作为竞争事件,对临床和心律结果进行了比较。采用反概率治疗加权法(IPTW)减轻选择偏差:结果:接受LA消融术的患者年龄较轻,房颤持续时间较短或需要同时接受三尖瓣手术的患者较少。调整后的分析表明,LA消融术与较低的早期起搏器植入风险相关(几率比为0.16;95%置信区间[CI]为0.07-0.38;P<0.05)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The long-term impact of lesion set in the surgical ablation of atrial fibrillation during mitral valve surgery: multi-center propensity-score weighted study.

Objective: This study aimed to assess the effect of the lesion sets for surgical ablation (SA) of atrial fibrillation (AF) on long-term outcomes and identify the optimal lesion set.

Methods: Between 2005 and 2017, 1825 patients underwent SA concomitant to mitral valve (MV) surgery in the participating institutions. Of these, 529 underwent left atrial (LA) ablation, whereas the remainder had biatrial (BA) ablation. The clinical and rhythm outcomes were compared, considering death as a competing event. Inverse probability treatment weighting (IPTW) was used to mitigate the selection bias.

Results: The patients undergoing LA ablation were younger and less frequently had long-standing AF with a shorter duration or required concomitant tricuspid valve surgery. Adjusted analysis showed that LA ablation was associated with a lower risk of early pacemaker implantation (odds ratio, 0.16; 95% confidence interval [CI], 0.07-0.38; p<0.001) than BA ablation. Over a median follow-up of 70.4 months (interquartile 44.1-111.2 months), the LA ablation group presented a higher risk of AF recurrence (subdistribution hazard ratio [SHR]1.26; 95% CI 1.12-1.41; p<0.001), with a 5-year cumulative incidence of 34.2% compared to 28.6% in the BA group. The risk of late mortality (SHR, 1.17; 95% CI, 0.74-1.86; p=0.507) and stroke (SHR, 1.21; 95% CI, 0.82-1.79; p=0.345) did not differ between the groups CONCLUSION: In patients undergoing SA concomitant to MV surgery, both lesion sets provided comparable incidence of mortality and stroke. However, BA ablation was associated with a superior rhythm outcome at the expense of a higher risk of early pacemaker implantation.

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来源期刊
CiteScore
11.20
自引率
10.00%
发文量
1079
审稿时长
68 days
期刊介绍: The Journal of Thoracic and Cardiovascular Surgery presents original, peer-reviewed articles on diseases of the heart, great vessels, lungs and thorax with emphasis on surgical interventions. An official publication of The American Association for Thoracic Surgery and The Western Thoracic Surgical Association, the Journal focuses on techniques and developments in acquired cardiac surgery, congenital cardiac repair, thoracic procedures, heart and lung transplantation, mechanical circulatory support and other procedures.
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