婴儿的六氟化硫多次呼吸冲洗和冲洗结果不能互换。

IF 2.3 4区 医学 Q3 BIOPHYSICS
Anne-Christianne Kentgens, Florian Wyler, Marc-Alexander Oestreich, Philipp Latzin, Sophie Yammine
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引用次数: 0

摘要

六氟化硫(SF6)多次呼吸冲洗(MBW)可评估通气不均匀性,是阻塞性呼吸系统疾病的早期标志。主要结果通常由冲洗得出,目前还不清楚之前的 SF6 冲洗是否能提供类似的估计值。我们的目的是评估分别使用 WBreath(ndd Medizintechnik AG,瑞士苏黎世)和 Spiroware(Eco Medics AG,瑞士 Duernten)MBW 设置测量的婴儿 SF6-MBW 数据在冲洗和冲洗阶段的主要 SF6-MBW 结果的可比性。我们评估了健康婴儿和囊性纤维化婴儿(CF)现有 SF6-MBW 数据的洗入和洗出间肺清除指数(LCI)和功能残余容量(FRC)的平均相对差异。我们评估了这些差异是否超过了洗脱衍生结果的平均相对试验内差异,这可归因于自然变异。我们还使用儿科肺模拟器探讨了非生理因素。 主要结果:在两种设置下,洗入和洗出的LCI和FRC不具可比性。WBreath和Spiroware在洗入和洗出之间的LCI平均差异(SD)分别为2.3(10.8)%和-9.7(8.0)%,而在FRC方面,WBreath为-4.7(7.8)%,Spiroware为-2.3(9.7)%。这些差异超过了洗脱衍生结果的试验内差异。在小儿肺模拟器中,冲洗和冲出的结果也不具可比性。由于生理和非生理因素的相互作用,冲洗和冲出的结果不具可比性,不能互换使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sulfur hexafluoride multiple breath washin and washout outcomes in infants are not interchangeable.

Objective.Sulfur hexafluoride (SF6) multiple-breath washout (MBW) assesses ventilation inhomogeneity, as an early marker of obstructive respiratory diseases. Primary outcomes are customarily washout-derived, and it is unclear whether the preceding SF6-washin can provide similar estimates. We aimed to assess comparability of primary SF6-MBW outcomes between washin and washout phases of infant SF6-MBW data measured with the WBreath (ndd Medizintechnik AG, Zurich, Switzerland) and Spiroware (Eco Medics AG, Duernten, Switzerland) MBW-setups, respectively.Approach.We assessed mean relative differences in lung clearance index (LCI) and functional residual capacity (FRC) between the washin and washout of existing SF6-MBW data from healthy infants and infants with cystic fibrosis (CF). We assessed whether these differences exceeded the mean relative within-test between-trial differences of washout-derived outcomes, which can be attributed to natural variability. We also explored non-physiological factors using a pediatric lung simulator.Main results.LCI and FRC from washin and washout were not comparable, for both setups. The mean difference (SD) in LCI between washin and washout was 2.3(10.8)% for WBreath and -9.7(8.0)% for Spiroware, while in FRC it was -4.7(8.4)% for WBreath and -2.3(9.7)% for Spiroware. These differences exceeded the within-test between-trial differences in washout-derived outcomes. Outcomes from washin and washout were also not comparable in a pediatric lung simulator.Significance.Outcomes of the washin and washout were not comparable due to an interplay of physiological and non-physiological factors, and cannot be used interchangeably.

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来源期刊
Physiological measurement
Physiological measurement 生物-工程:生物医学
CiteScore
5.50
自引率
9.40%
发文量
124
审稿时长
3 months
期刊介绍: Physiological Measurement publishes papers about the quantitative assessment and visualization of physiological function in clinical research and practice, with an emphasis on the development of new methods of measurement and their validation. Papers are published on topics including: applied physiology in illness and health electrical bioimpedance, optical and acoustic measurement techniques advanced methods of time series and other data analysis biomedical and clinical engineering in-patient and ambulatory monitoring point-of-care technologies novel clinical measurements of cardiovascular, neurological, and musculoskeletal systems. measurements in molecular, cellular and organ physiology and electrophysiology physiological modeling and simulation novel biomedical sensors, instruments, devices and systems measurement standards and guidelines.
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