一石二鸟:回应 Gurunthalingam 等人致编辑的信

IF 3.2 2区 医学 Q2 CLINICAL NEUROLOGY
Wenting Xu, Lin Wang, Cheng Tan
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引用次数: 0

摘要

将使用加巴喷丁类药物进行围手术期疼痛管理并观察到瘙痒作为阿片类药物不良反应的研究纳入其中符合纳入标准。我们认为,将这些研究整合在一起,可以深入了解加巴喷丁类药物在控制阿片类药物引起的瘙痒症方面的双重作用,从而有效地从单一干预措施中获得多种益处。尽管原始研究的主要关注点是围手术期加巴喷丁类药物的镇痛效果,但它们也记录了阿片类药物引起的瘙痒症的发生率,作为我们综述的关键结果测量指标。出乎意料的是,我们的汇总分析发现,使用加巴喷丁类药物后,阿片类药物引起的瘙痒发生率在统计学上有显著降低。关于加巴喷丁类药物给药时间不一致可能会影响其对阿片类药物引起的瘙痒的疗效评估这一问题,我们认为所有这些病例,无论是术前、术后给药,还是同时给药,都属于围手术期使用加巴喷丁类药物的范畴。因此,给药时间并不是一个变量;相反,是否在围手术期使用加巴喷丁类药物才是影响瘙痒发生率这一结果指标的变量。对于我们提取的数据与原始研究之间存在差异的部分,如用药时间和报告结果,我们也进行了解释。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
One Stone, Two Birds: Response to Letter to the Editor by Gurunthalingam et al.
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来源期刊
CiteScore
8.90
自引率
6.40%
发文量
821
审稿时长
26 days
期刊介绍: The Journal of Pain and Symptom Management is an internationally respected, peer-reviewed journal and serves an interdisciplinary audience of professionals by providing a forum for the publication of the latest clinical research and best practices related to the relief of illness burden among patients afflicted with serious or life-threatening illness.
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