研究利用吸疱膜进行自体非培养非胰蛋白酶表皮细胞移植(焦德普尔技术)对稳定期白癜风的疗效。

Q3 Medicine
Journal of Cutaneous and Aesthetic Surgery Pub Date : 2024-07-01 Epub Date: 2024-08-29 DOI:10.25259/jcas_152_22
Harshvardhan Singh, Chinmai Yadav, Rahul Singrodia, Dilip Kachhawa, Pankaj Rao
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引用次数: 0

摘要

研究目的本研究旨在评估自体非培养黑色素角质细胞移植(JT)与吸水泡膜作为生物敷料对稳定期白癜风斑块的疗效:该研究在焦特普尔的马图拉-达斯-马图尔医院(MDM)进行,共治疗了43个稳定期白癜风斑块。这是一项前瞻性单臂干预研究。所有患者均接受了临床检查,并在获得病史和知情同意后才开始手术:结果:约95%的白斑色素再沉着>50%,83.72%的白斑色素再沉着良好至极佳。约 88% 的斑块显示出良好的颜色匹配度,皮肤科生活质量指数(DLQI)也有极好的下降。本研究未观察到严重的并发症。供体和受体区域最常见的并发症是疼痛:我们的研究表明,将 JT 与吸疱表皮移植术结合使用是一种比较有效的技术,其再色素沉着效果好(再色素沉着程度≥75%)、颜色匹配、副作用少、患者满意度高且 DLQI 下降。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
To study the efficacy of autologous non-cultured nontrypsinized epidermal cell grafting (Jodhpur technique) by using of suction blister membrane in stable vitiligo.

Objectives: This study aimed to evaluate the efficacy of autologous non-cultured non-trypsinized melanocytekeratinocyte grafting (JT) with suction blister membrane as biological dressing in stable vitiligo patches.

Material and methods: The study was conducted at Mathura Das Mathur Hospital (MDM), Jodhpur, on 43 patches of Stable vitiligo. It was a prospective single-arm interventional study. All patients were examined clinically and history and informed consent were taken before starting the procedure.

Results: About 95% of patches showed >50% repigmentation with 83.72% having good to excellent repigmentation. About 88% of patches showed good color matches with an excellent decline in Dermatology Life Quality Index (DLQI). No serious complication was observed in the present study. The most common complication observed both in the donor and recipient area was pain.

Conclusion: Our study indicates that combining JT with suction blister epidermal grafting is a comparatively effective technique in terms of good repigmentation (≥75% extent of repigmentation), color match, fewer side effects, good patient satisfaction, and DLQI reduction.

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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
60
审稿时长
29 weeks
期刊介绍: The journal will cover aspects of Dermatosurgery and Aesthetic surgery, including cutaneous surgical procedures, lasers, light based treatments and aesthetic treatments. Authors of articles addressing topics such as skin tumours, pigmentary disorders, histopathology, diagnostic techniques, drugs, applications of cosmeceuticals surgical aspects, including pre and post procedural care are highly encouraged to submit with us. The journal also publishes articles on topics in allied specialities suh as plastic surgery, maxillofacial surgery vascular surgery, oculoplastic surgery etc. that are relevant to Dermatosurgery. The journal gives preference to clinically oriented studies over experimental and animal studies. The Journal would publish peer-reviewed Original Research Articles, Systematic reviews, Narrative Reviews, Case reports, Innovations and Debates. Letters to the editor, practice points, pearls in cutaneous and aesthetic surgery, quiz page, images, novel techniques, newer uses of instruments and video presentations and ethical aspects of cutaneous and aesthetic surgery are also invited.
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