研究比较 50%乙醇酸和 65%三氯乙酸通过 CROSS 技术治疗萎缩性痤疮疤痕的疗效。

Q3 Medicine
Journal of Cutaneous and Aesthetic Surgery Pub Date : 2024-07-01 Epub Date: 2024-08-29 DOI:10.25259/jcas_18_21
Gourab Roy, Tirthankar Gayen, Sumit Sen, Olympia Rudra
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引用次数: 0

摘要

目的:要治疗痤疮疤痕并取得令人满意的效果,往往具有挑战性。皮肤疤痕的化学重建(CROSS)技术一直使用高浓度的三氯乙酸(TCA),但往往会产生令人无法接受的副作用。在印度人群中,使用 50%羟基乙酸(GA)治疗痤疮疤痕的数据十分匮乏。本研究旨在评估使用 50%乙醇酸与使用 65% TCA 后痤疮疤痕的临床反应:研究对象为年龄在 16-45 岁之间、患有痤疮疤痕且在过去 1 年内未接受过治疗的男女患者。受试者被分配接受其中一种配方(50% GA [A 组] 和 65% TCA [B 组])。在第 1 天和第 35 天,根据患者的四点目测评估和医生使用 Goodman-Baron 全球痤疮疤痕定性分级表进行的评估,对疤痕进行分级。该过程每两周重复一次,连续进行三次。数据采用 Statistica 第 6 版(俄克拉荷马州塔尔萨:StatSoft 公司,2001 年)进行分析:结果:患者的视觉改善量表显示,A 组有 41.38%(12 人)改善一般,而 B 组有 58.06%(18 人)改善良好;根据 Goodman-Baron 量表分级,B 组有 9.68%(3 人)出现四级变化:结论:65% TCA 的改善效果最佳。结论:65% 三氯乙酸的改善效果最好,而 65% 三氯乙酸的不良反应较多,尤其是痤疮样糜烂,这在之前的研究中是缺乏的。GA 可以作为 TCA 的一种更安全的替代品,而且效果可以接受。我们的研究为今后研究不同浓度的 GA 作为 CROSS 药剂打开了一扇科学之窗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study to compare the efficacy of 50% glycolic acid with 65% trichloroacetic acid in the treatment of atrophic acne scar by CROSS technique.

Objectives: Acne scars often become challenging to treat with satisfactory results. The chemical reconstruction of skin scars (CROSS) technique has been used with high concentrations of trichloroacetic acid (TCA) which often produces unacceptable side effects. There is a dearth of data, with 50% glycolic acid (GA) for the same indication in the management of acne scars in the Indian population. This study aimed to assess the clinical response of acne scars after the application of 50% GA with that after the use of 65% TCA in a similar manner.

Material and methods: An institution-based prospective comparative study was performed with patients aged 16-45 years of either sex with acne scars and not been treated within the past 1 year. Subjects were assigned to receive one of the formulations (50% GA [Group A] and 65% TCA [Group B]). Grading of scars was done on day 1 and day 35 based on patients' assessment on a four-point visual scale and physicians' assessment by the Goodman-Baron qualitative global acne scar grading scale. The procedure was repeated every fortnightly for three such. Data were analyzed by Statistica version 6 (Tulsa, Oklahoma: StatSoft Inc. 2001).

Results: The visual improvement scale of patients showed 41.38% (n = 12) fair improvement in group A, whereas 58.06% (n = 18) showed good improvement in group B. Grading by the Goodman-Baron scale showed 9.68% (n = 3) showed four grade changes in group B.

Conclusion: Improvement is best observed with 65% TCA. Adverse effects were noted more with 65% TCA, especially acneiform eruption which was lacking in the previous studies. GA can be a safer alternative to TCA with acceptable results. Our study opens the scientific window for future research on different concentrations of GA as a CROSS agent.

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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
60
审稿时长
29 weeks
期刊介绍: The journal will cover aspects of Dermatosurgery and Aesthetic surgery, including cutaneous surgical procedures, lasers, light based treatments and aesthetic treatments. Authors of articles addressing topics such as skin tumours, pigmentary disorders, histopathology, diagnostic techniques, drugs, applications of cosmeceuticals surgical aspects, including pre and post procedural care are highly encouraged to submit with us. The journal also publishes articles on topics in allied specialities suh as plastic surgery, maxillofacial surgery vascular surgery, oculoplastic surgery etc. that are relevant to Dermatosurgery. The journal gives preference to clinically oriented studies over experimental and animal studies. The Journal would publish peer-reviewed Original Research Articles, Systematic reviews, Narrative Reviews, Case reports, Innovations and Debates. Letters to the editor, practice points, pearls in cutaneous and aesthetic surgery, quiz page, images, novel techniques, newer uses of instruments and video presentations and ethical aspects of cutaneous and aesthetic surgery are also invited.
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