揭开复杂的面纱:探索蒽环类药物诱发心脏毒性的机制。

IF 2.4 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Rohit Tayal, Ashi Mannan, Shareen Singh, Sonia Dhiman, Thakur Gurjeet Singh
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引用次数: 0

摘要

癌症和心脏病是导致疾病和死亡的主要原因,两者的并存因化疗的有害影响而进一步加剧。蒽环类药物诱发的心脏毒性是治疗不同类型癌症的高效疗法所产生的一种令人遗憾的副作用;由于心脏毒性的风险相当大,它给临床医生和患者都带来了巨大的挑战。尽管在了解这些机制方面取得了重大进展,但在确定有效的预防和治疗策略方面仍然存在挑战,因此,即使经过三十年的全球深入研究,它仍然是一个需要继续研究的课题。所探索的分子靶点和信号通路为开发靶向疗法提供了启示,强调了继续研究以弥合临床前理解和临床应用之间差距的必要性。这篇综述全面探讨了蒽环类药物诱发心脏毒性的复杂机制,阐明了导致不良细胞事件(包括心脏毒性和死亡)的各种信号通路之间的相互作用。它强调了与氧化应激、炎症、细胞凋亡和细胞应激反应相关的通路的广泛参与,为减轻蒽环类药物诱发的心脏并发症提供了潜在的和尚未开发的治疗干预靶点。全面了解蒽环类药物与这些复合信号通路之间的相互作用对于制定预防或减轻相关心脏毒性的策略至关重要。还需要进一步的研究来概述这些通路的具体作用,并确定潜在的治疗靶点,以提高基于蒽环类的癌症治疗的安全性和有效性。最终,对蒽环类药物诱导的心脏毒性机制的进一步了解将有助于开发更有效的预防和治疗方法,从而改善接受蒽环类药物化疗的癌症患者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unveiling the Complexities: Exploring Mechanisms of Anthracycline-Induced Cardiotoxicity.

The coexistence of cancer and heart disease, both prominent causes of illness and death, is further exacerbated by the detrimental impact of chemotherapy. Anthracycline-induced cardiotoxicity is an unfortunate side effect of highly effective therapy in treating different types of cancer; it presents a significant challenge for both clinicians and patients due to the considerable risk of cardiotoxicity. Despite significant progress in understanding these mechanisms, challenges persist in identifying effective preventive and therapeutic strategies, rendering it a subject of continued research even after three decades of intensive global investigation. The molecular targets and signaling pathways explored provide insights for developing targeted therapies, emphasizing the need for continued research to bridge the gap between preclinical understanding and clinical applications. This review provides a comprehensive exploration of the intricate mechanisms underlying anthracycline-induced cardiotoxicity, elucidating the interplay of various signaling pathways leading to adverse cellular events, including cardiotoxicity and death. It highlights the extensive involvement of pathways associated with oxidative stress, inflammation, apoptosis, and cellular stress responses, offering insights into potential and unexplored targets for therapeutic intervention in mitigating anthracycline-induced cardiac complications. A comprehensive understanding of the interplay between anthracyclines and these complexes signaling pathways is crucial for developing strategies to prevent or mitigate the associated cardiotoxicity. Further research is needed to outline the specific contributions of these pathways and identify potential therapeutic targets to improve the safety and efficacy of anthracycline-based cancer treatment. Ultimately, advancements in understanding anthracycline-induced cardiotoxicity mechanisms will facilitate the development of more efficacious preventive and treatment approaches, thereby improving outcomes for cancer patients undergoing anthracycline-based chemotherapy.

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来源期刊
Current Cardiology Reviews
Current Cardiology Reviews CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.70
自引率
10.50%
发文量
117
期刊介绍: Current Cardiology Reviews publishes frontier reviews of high quality on all the latest advances on the practical and clinical approach to the diagnosis and treatment of cardiovascular disease. All relevant areas are covered by the journal including arrhythmia, congestive heart failure, cardiomyopathy, congenital heart disease, drugs, methodology, pacing, and preventive cardiology. The journal is essential reading for all researchers and clinicians in cardiology.
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