对体弱女性患者进行全身麻醉诱导时使用环丙酚的有效性和安全性:一项前瞻性随机对照试验。

IF 2.3 3区 医学 Q2 ANESTHESIOLOGY
Yu Wei, Lijie Jia, Shiping Cheng, Wei Ma, Xiaohu An, Zifeng Xu
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引用次数: 0

摘要

背景:新近开发的麻醉剂异丙酚在疗效和安全性方面并不比异丙酚差。然而,以往使用环丙酚的临床经验大多基于体格健壮的人群。本研究旨在探讨异丙酚用于女性虚弱患者麻醉诱导的有效性和安全性:这项前瞻性随机对照试验纳入了为妇科手术进行择期全身麻醉的体弱患者。体弱程度采用改良体弱指数进行评估。在麻醉诱导过程中,患者被随机注射异丙酚(2 毫克/千克)或环丙酚(0.5 毫克/千克)。麻醉深度由双谱指数持续监测。主要结果是麻醉诱导期间的最低收缩压(SBP)。次要结果包括全身麻醉诱导失败和不良事件的发生率:在 69 名入选的虚弱患者中,有 67 人被纳入最终分析。两组患者的麻醉诱导成功率均为 100%。环丙酚组的最低 SBP 明显高于异丙酚组(分别为 103 [96-110] mmHg vs. 90 [85-98] mmHg;P 结论:本研究结果表明,环丙酚组的麻醉诱导成功率高于异丙酚组(分别为 103 [96-110] mmHg vs. 90 [85-98] mmHg;P):本研究结果表明,环丙酚对体弱患者诱导全身麻醉的疗效与异丙酚相当,且血液动力学更稳定:该试验在患者入组前已在中国临床试验注册中心 ( www.chictr.org.cn ) 注册(临床试验编号:ChiCTR2300075271):ChiCTR2300075271; https://www.chictr.org.cn/showproj.html?proj=205160 ,主要研究者姓名:徐子峰,注册日期:2023 年 8 月 31 日):31/08/2023).
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy and safety of ciprofol for general anesthesia induction in female patients with frailty: a prospective randomized controlled trial.

Background: Ciprofol, a recently developed anesthetic agent, is not inferior to propofol in terms of efficacy and safety. However, most previous clinical experience with ciprofol was based on a robust population. This study aimed to investigate the efficacy and safety of ciprofol for anesthesia induction in female patients with frailty.

Methods: This prospective randomized controlled trial included patients with frailty undergoing elective general anesthesia for gynecological surgery. Frailty was assessed using the modified frailty index. The patients were randomly administered propofol (2 mg/kg) or ciprofol (0.5 mg/kg) during anesthesia induction. The depth of anaesthesia was continually monitored by the bispectral index. The primary outcome was the lowest systolic blood pressure (SBP) during anesthesia induction. Secondary outcomes included the incidence of general anesthesia induction failure and adverse events.

Results: Among the 69 enrolled patients with frailty, 67 were included in the final analysis. The success rate of anesthesia induction was 100% in both groups. The lowest SBP was significantly higher in the ciprofol group than in the propofol group (103 [96-110] vs. 90 [85-98] mmHg, respectively; P < 0.001), suggesting that the former caused less inhibition of hemodynamics during anesthesia induction in patients with frailty. The incidence of injection pain was lower in the ciprofol group than in the propofol group (3 [8.8%] vs. 11 patients [33.3%], respectively; P = 0.014).

Conclusions: The results of this study suggest that the efficacy of ciprofol for inducing general anesthesia in patients with frailty is comparable to that of propofol, with more stable hemodynamics.

Trial registration: The trial was registered, before patient enrollment, in the Chinese Clinical Trial Registry ( www.chictr.org.cn ) (Clinical trial number: ChiCTR2300075271; https://www.chictr.org.cn/showproj.html?proj=205160 , principal investigator's name: Zifeng Xu, date of registration: 31/08/2023).

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来源期刊
BMC Anesthesiology
BMC Anesthesiology ANESTHESIOLOGY-
CiteScore
3.50
自引率
4.50%
发文量
349
审稿时长
>12 weeks
期刊介绍: BMC Anesthesiology is an open access, peer-reviewed journal that considers articles on all aspects of anesthesiology, critical care, perioperative care and pain management, including clinical and experimental research into anesthetic mechanisms, administration and efficacy, technology and monitoring, and associated economic issues.
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