益生菌和多西环素联合疗法对酒渣鼻肠道-皮肤轴的影响

IF 5 2区 生物学 Q1 MICROBIOLOGY
mSystems Pub Date : 2024-10-30 DOI:10.1128/msystems.01201-24
Jie Yu, Yan Duan, Meng Zhang, Qi Li, Miao Cao, Weixin Song, Feiyan Zhao, Lai-Yu Kwok, Heping Zhang, Ruiya Li, Zhihong Sun
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引用次数: 0

摘要

红斑痤疮是一种慢性炎症性皮肤病,以面部红斑、毛细血管扩张和痤疮样糜烂为特征,影响着全球数百万人。虽然抗生素仍是一种常见的治疗方法,但长期使用会产生严重的不良影响,并可能导致抗生素耐药性。本研究评估了益生菌和强力霉素联合治疗对酒渣鼻的影响,强调了肠道-皮肤轴。60名酒糟鼻患者被随机分配到益生菌组、安慰剂组或对照组。在接受了为期两周的强力霉素治疗后,参与者接受了为期三个月的干预治疗,要么服用安慰剂,要么服用益生菌,要么不再接受治疗。临床结果在基线和 14 周干预后进行了评估。我们的研究结果表明,服用益生菌可改善面部皮肤状况、缓解炎症、减少面部皮肤微生物群多样性,同时提高肠道微生物群的异质性。多变量分析确定了区分益生菌组与对照组和安慰剂组的微生物标志物,其中一些标志物与皮肤健康参数相关。益生菌干预后,一些与面部皮肤相关的类群,如水杆菌、UBA4096 sp.此外,益生菌组的粪便微生物群中富含特定的肠道微生物,包括副胰腺炎链球菌、斜管酵母菌和卡氏酵母菌,而硫化乳杆菌的数量则有所减少。这些变化与面部皮脂水平降低和医生总体评估得分降低有关。最后,与对照组和安慰剂组相比,益生菌组检测到的抗生素耐药基因,尤其是四环素耐药基因较少。我们的研究支持肠道-皮肤轴的存在,并支持应用益生菌治疗酒渣鼻:这项研究阐明了红斑痤疮的治疗方法,提出了益生菌与强力霉素同时使用的新见解,显示了益生菌在缓解症状和减轻患者炎症方面的双重功效。研究绘制了益生菌诱导的肠道和皮肤微生物群变化图,强调了与皮肤健康改善相关的微生物变化。最重要的是,它揭示了益生菌对肠道-皮肤轴的调节作用,提出了一种在酒糟鼻治疗中抑制抗生素耐药性的方法。这项研究为益生菌在红斑痤疮中的应用提供了有力的证据,推动了我们对肠道与皮肤关系的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of combined probiotics and doxycycline therapy on the gut-skin axis in rosacea.

Rosacea is a chronic inflammatory skin condition marked by facial erythema, telangiectasia, and acne-like eruptions, affecting millions worldwide. While antibiotics remain a common treatment, prolonged use has significant adverse effects and can lead to antibiotic resistance. This study evaluated the impact of combined probiotics and doxycycline treatment on rosacea, emphasizing the gut-skin axis. Sixty rosacea patients were randomly assigned to the probiotic, placebo, or control groups. After a 2-week doxycycline treatment, participants underwent a 3-month intervention with either a placebo, probiotic, or no further treatment. Clinical outcomes were assessed at baseline and after the 14-week intervention. Our results showed that probiotic administration improved facial skin conditions, alleviated inflammation, and reduced facial skin microbiota diversity while enhancing gut microbiota heterogeneity. Multivariate analysis identified microbial markers distinguishing the probiotic group from the control and placebo groups, and some markers were associated with skin health parameters. After the probiotic intervention, some facial skin-associated taxa, such as Aquabacterium sp., UBA4096 sp. 1, UBA4096 sp. 2, and Yimella indica, decreased in abundance. Additionally, the fecal microbiota of the probiotic group was enriched in specific gut microbes, including Streptococcus parasanguinis, Erysipelatoclostridium ramosum, and Coprobacillus cateniformis, while showing a reduced abundance of Bacteroides vulgatus. These changes were associated with reduced facial sebum levels and a lower physician's global assessment score. Finally, fewer antibiotic resistance genes, particularly tetracycline resistance genes, were detected in the probiotic group compared with the control and placebo groups. Our study supports the existence of a gut-skin axis and the application of probiotics in managing rosacea.

Importance: This research elucidates rosacea management with novel insights into probiotic use alongside doxycycline, showing dual benefits in symptom relief and inflammation reduction in patients. The study maps probiotic-induced shifts in gut and skin microbiota, underscoring microbial shifts correlating with skin health improvements. Crucially, it deciphers the gut-skin axis modulation by probiotics, proposing a method to curb antibiotic resistance in rosacea therapies. This study furnishes robust evidence for probiotics in rosacea, advancing our grasp of the gut-skin relationship.

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来源期刊
mSystems
mSystems Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
10.50
自引率
3.10%
发文量
308
审稿时长
13 weeks
期刊介绍: mSystems™ will publish preeminent work that stems from applying technologies for high-throughput analyses to achieve insights into the metabolic and regulatory systems at the scale of both the single cell and microbial communities. The scope of mSystems™ encompasses all important biological and biochemical findings drawn from analyses of large data sets, as well as new computational approaches for deriving these insights. mSystems™ will welcome submissions from researchers who focus on the microbiome, genomics, metagenomics, transcriptomics, metabolomics, proteomics, glycomics, bioinformatics, and computational microbiology. mSystems™ will provide streamlined decisions, while carrying on ASM''s tradition of rigorous peer review.
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