哺乳动物卵巢和卵母细胞大分子在整个生殖生命周期中的超长寿命。

IF 6.4 1区 生物学 Q1 BIOLOGY
eLife Pub Date : 2024-10-31 DOI:10.7554/eLife.93172
Ewa K Bomba-Warczak, Karen M Velez, Luhan T Zhou, Christelle Guillermier, Seby Edassery, Matthew L Steinhauser, Jeffrey N Savas, Francesca E Duncan
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引用次数: 0

摘要

导致与年龄相关的女性生殖系统衰退的机制非常复杂,但蛋白质平衡失调是一个主要原因。我们阐明了哺乳动物卵巢和配子在整个生殖生命周期中持续存在的异常稳定的蛋白质、结构和大分子。卵巢在卵泡和卵泡外环境中都表现出局部结构和细胞类型特异性的稳定大分子富集。此外,卵巢和卵母细胞都蕴藏着一系列寿命特别长的蛋白质,包括细胞骨架、线粒体和卵母细胞衍生蛋白质。这些长寿命分子的特殊持久性表明,它们在生殖组织的终生维持和随年龄而退化的过程中发挥着关键作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan.

The mechanisms contributing to age-related deterioration of the female reproductive system are complex, however aberrant protein homeostasis is a major contributor. We elucidated exceptionally stable proteins, structures, and macromolecules that persist in mammalian ovaries and gametes across the reproductive lifespan. Ovaries exhibit localized structural and cell-type-specific enrichment of stable macromolecules in both the follicular and extrafollicular environments. Moreover, ovaries and oocytes both harbor a panel of exceptionally long-lived proteins, including cytoskeletal, mitochondrial, and oocyte-derived proteins. The exceptional persistence of these long-lived molecules suggest a critical role in lifelong maintenance and age-dependent deterioration of reproductive tissues.

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来源期刊
eLife
eLife BIOLOGY-
CiteScore
12.90
自引率
3.90%
发文量
3122
审稿时长
17 weeks
期刊介绍: eLife is a distinguished, not-for-profit, peer-reviewed open access scientific journal that specializes in the fields of biomedical and life sciences. eLife is known for its selective publication process, which includes a variety of article types such as: Research Articles: Detailed reports of original research findings. Short Reports: Concise presentations of significant findings that do not warrant a full-length research article. Tools and Resources: Descriptions of new tools, technologies, or resources that facilitate scientific research. Research Advances: Brief reports on significant scientific advancements that have immediate implications for the field. Scientific Correspondence: Short communications that comment on or provide additional information related to published articles. Review Articles: Comprehensive overviews of a specific topic or field within the life sciences.
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