远程缺血预处理对重度颈动脉狭窄患者脑循环时间的影响:RIC-CCT试验结果

IF 11.7 1区 医学 Q1 CELL BIOLOGY
Cell Reports Medicine Pub Date : 2024-11-19 Epub Date: 2024-10-28 DOI:10.1016/j.xcrm.2024.101796
Quan-Ying Liu, Yu Cui, Wei Li, Jing Qiu, Thanh N Nguyen, Hui-Sheng Chen
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引用次数: 0

摘要

严重颈内动脉狭窄(sICAS)患者的脑循环时间(CCT)与脑高灌注综合征有关。本研究旨在探讨远程缺血预处理(RIC)对 sICAS 患者 CCT 的影响。患者被随机分配到远程缺血预处理组(在颈动脉支架植入术[CAS]前作为标准药物治疗的辅助治疗,每天两次远程缺血预处理,持续2-4天)和对照组。结果显示,RIC 可使狭窄侧的 CCT(sCCT)从基线到 CAS 前显著下降,而且 CAS 后 RIC 组与对照组相比,脑部计算机断层扫描(CT)对比剂染色的发生率更低。此外,一些血清生物标志物的明显变化表明,抗神经炎症、抗氧化应激、保护内皮损伤和改善脑的自动调节功能可能与 RIC 的效果有关。这些发现为 RIC 可调节 sICAS 患者的脑循环提供了佐证。本研究已在 ClinicalTrials.gov 注册(NCT05451030)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of remote ischemic preconditioning on cerebral circulation time in severe carotid artery stenosis: Results from the RIC-CCT trial.

In patients with severe internal carotid artery stenosis (sICAS), cerebral circulation time (CCT) is associated with cerebral hyperperfusion syndrome. This study aims to investigate the effect of remote ischemic preconditioning (RIC) on CCT in patients with sICAS. Patients are randomly assigned to the RIC group (RIC twice daily, for 2-4 days before carotid artery stenting [CAS] as an adjunct to standard medical therapy) and the control group. The results show that RIC produces a significant decrease in CCT of the stenosis side (sCCT) from baseline to pre-CAS, and the occurrence of contrast staining on brain computed tomography (CT) is lower in RIC versus control group after CAS. In addition, significant changes in some serum biomarkers suggest that anti-neuroinflammation, anti-oxidative stress, protecting endothelial injury, and improving cerebral autoregulation may be associated with the effect of RIC. These findings provide supporting evidence that RIC can modulate cerebral circulation in patients with sICAS. This study was registered at ClinicalTrials.gov (NCT05451030).

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来源期刊
Cell Reports Medicine
Cell Reports Medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
15.00
自引率
1.40%
发文量
231
审稿时长
40 days
期刊介绍: Cell Reports Medicine is an esteemed open-access journal by Cell Press that publishes groundbreaking research in translational and clinical biomedical sciences, influencing human health and medicine. Our journal ensures wide visibility and accessibility, reaching scientists and clinicians across various medical disciplines. We publish original research that spans from intriguing human biology concepts to all aspects of clinical work. We encourage submissions that introduce innovative ideas, forging new paths in clinical research and practice. We also welcome studies that provide vital information, enhancing our understanding of current standards of care in diagnosis, treatment, and prognosis. This encompasses translational studies, clinical trials (including long-term follow-ups), genomics, biomarker discovery, and technological advancements that contribute to diagnostics, treatment, and healthcare. Additionally, studies based on vertebrate model organisms are within the scope of the journal, as long as they directly relate to human health and disease.
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