组氨酸诱导单线态氧和超氧自由基生成的六核铱(III)团簇

IF 2.4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Polyhedron Pub Date : 2024-10-22 DOI:10.1016/j.poly.2024.117264

Dan Yang , Meng Zhong , Zhiguo Zhou , Xu Chen

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引用次数: 0

摘要

光敏剂（PSs）在光动力疗法（PDT）中发挥着关键作用。光动力疗法通常依赖于局部的氧气浓度。光敏剂面临的一大挑战是开发不依赖氧气的光敏剂，这种光敏剂能在缺氧的肿瘤微环境中发挥良好作用。在这项研究中，六核 Ir(III) 簇（Ir6）对组氨酸和富含组氨酸（His-rich）的蛋白质具有高度选择性，形成 [Ir(bpy)2(His)] 的单核 Ir(III) 复合物。在对组氨酸或富含组氨酸的蛋白质产生选择性反应后，[Ir(bpy)2(His)] 会产生单线态氧（1O2）和超氧（O2-）。这项工作为 Ir6 在Ι型和ΙΙ型协同光动力疗法中的潜在应用开辟了一条途径。

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A hexanuclear Iridium(III) cluster for histidine-induced singlet oxygen and superoxide radicals generation

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A hexanuclear Iridium(III) cluster for histidine-induced singlet oxygen and superoxide radicals generation

Photosensitizers (PSs) play key roles in photodynamic therapy (PDT). PDT is typically reliant on the local concentration of oxygen. A big challenge for PSs is to develop oxygen-independent photosensitizers, which can work well in hypoxic tumor microenvironment. In this piece of work, a hexanuclear Ir(III) cluster (Ir6) is highly selective towards histidine and histidine-rich (His-rich) proteins to form mononuclear Ir(III) complexes of [Ir(bpy)₂(His)]. After the selective response to histidine or his-rich proteins, [Ir(bpy)₂(His)] generates both singlet oxygen(¹O₂) and superoxide (O₂⁻). This work opens an avenue for the potential application of Ir6 for type Ι and ΙΙ synergic photodynamic therapy.

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来源期刊

Polyhedron 化学-晶体学

CiteScore

4.90

自引率

7.70%

发文量

515

审稿时长

2 months

期刊介绍： Polyhedron publishes original, fundamental, experimental and theoretical work of the highest quality in all the major areas of inorganic chemistry. This includes synthetic chemistry, coordination chemistry, organometallic chemistry, bioinorganic chemistry, and solid-state and materials chemistry. Papers should be significant pieces of work, and all new compounds must be appropriately characterized. The inclusion of single-crystal X-ray structural data is strongly encouraged, but papers reporting only the X-ray structure determination of a single compound will usually not be considered. Papers on solid-state or materials chemistry will be expected to have a significant molecular chemistry component (such as the synthesis and characterization of the molecular precursors and/or a systematic study of the use of different precursors or reaction conditions) or demonstrate a cutting-edge application (for example inorganic materials for energy applications). Papers dealing only with stability constants are not considered.