血清过氧化还原酶-4是氧化应激的生物标志物，与新发慢性肾脏病有关：一项基于人群的队列研究

IF 10.7 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Redox Biology Pub Date : 2024-10-22 DOI:10.1016/j.redox.2024.103408

Sem Geertsema , Paul Geertsema , Lyanne M. Kieneker , Amaal E. Abdulle , Sacha la Bastide-van Gemert , Stephan J.L. Bakker , Robin P.F. Dullaart , Gerard Dijkstra , Ron T. Gansevoort , Klaas Nico Faber , Harry van Goor , Arno R. Bourgonje

{"title":"血清过氧化还原酶-4是氧化应激的生物标志物，与新发慢性肾脏病有关：一项基于人群的队列研究","authors":"Sem Geertsema , Paul Geertsema , Lyanne M. Kieneker , Amaal E. Abdulle , Sacha la Bastide-van Gemert , Stephan J.L. Bakker , Robin P.F. Dullaart , Gerard Dijkstra , Ron T. Gansevoort , Klaas Nico Faber , Harry van Goor , Arno R. Bourgonje","doi":"10.1016/j.redox.2024.103408","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Chronic Kidney Disease (CKD), is often detected late due to its asymptomatic nature in the early stage of the disease. Overproduction of reactive oxygen species contributes to various pathological processes through oxidative stress (OS), impacting on cellular structures and functions with previous studies suggesting a link between OS and CKD progression. This study investigated the association between serum peroxiredoxin-4 (Prx4), a biomarker of oxidative stress, and the development of CKD in the general population.</div></div><div><h3>Methods</h3><div>This study featured data from the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) cohort, involving 5341 participants without CKD at baseline who underwent extensive prospective health evaluations. Serum Prx4 levels were quantified using an immunoluminometric assay. The primary outcome was new-onset CKD as defined by the composite of urinary albumin excretion (UAE) > 30 mg/24-h, an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m<sup>2</sup>, or both.</div></div><div><h3>Results</h3><div>Baseline median Prx4 level was 0.65 [interquartile range (IQR): 0.42–1.04] U/L, median eGFR was 98 [IQR: 87–108] mL/min/1.73 m<sup>2</sup>, and median UAE was 8.1 [IQR: 6.0–12.1] mg/L. During a median follow-up of 10.4 [IQR: 6.3–11.4] years, 867 (16.2 %) patients developed new-onset CKD. Higher Prx4 levels were significantly associated with an increased risk of CKD (hazard ratio (HR) per doubling: 1.29 [95 % confidence interval (CI): 1.21–1.37], p < 0.001), also after adjustment for risk factors including sex, smoking status, systolic blood pressure, high-sensitive C-reactive protein, chronic heart failure, diabetes mellitus and dyslipidemia (HR per doubling: 1.16 [1.06–1.24], p < 0.001). Sensitivity analyses confirmed the robustness of these findings.</div></div><div><h3>Conclusions</h3><div>This study supports the hypothesis that systemic oxidative stress, reflected by higher serum Prx4 levels, is significantly associated with the risk of developing CKD in the general population. These findings suggest that Prx4 could be a valuable biomarker for early risk stratification and prevention strategies in CKD management.</div></div>","PeriodicalId":20998,"journal":{"name":"Redox Biology","volume":"77 ","pages":"Article 103408"},"PeriodicalIF":10.7000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Serum peroxiredoxin-4, a biomarker of oxidative stress, associates with new-onset chronic kidney disease: A population-based cohort study\",\"authors\":\"Sem Geertsema , Paul Geertsema , Lyanne M. Kieneker , Amaal E. Abdulle , Sacha la Bastide-van Gemert , Stephan J.L. Bakker , Robin P.F. Dullaart , Gerard Dijkstra , Ron T. Gansevoort , Klaas Nico Faber , Harry van Goor , Arno R. Bourgonje\",\"doi\":\"10.1016/j.redox.2024.103408\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Chronic Kidney Disease (CKD), is often detected late due to its asymptomatic nature in the early stage of the disease. Overproduction of reactive oxygen species contributes to various pathological processes through oxidative stress (OS), impacting on cellular structures and functions with previous studies suggesting a link between OS and CKD progression. This study investigated the association between serum peroxiredoxin-4 (Prx4), a biomarker of oxidative stress, and the development of CKD in the general population.</div></div><div><h3>Methods</h3><div>This study featured data from the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) cohort, involving 5341 participants without CKD at baseline who underwent extensive prospective health evaluations. Serum Prx4 levels were quantified using an immunoluminometric assay. The primary outcome was new-onset CKD as defined by the composite of urinary albumin excretion (UAE) > 30 mg/24-h, an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m<sup>2</sup>, or both.</div></div><div><h3>Results</h3><div>Baseline median Prx4 level was 0.65 [interquartile range (IQR): 0.42–1.04] U/L, median eGFR was 98 [IQR: 87–108] mL/min/1.73 m<sup>2</sup>, and median UAE was 8.1 [IQR: 6.0–12.1] mg/L. During a median follow-up of 10.4 [IQR: 6.3–11.4] years, 867 (16.2 %) patients developed new-onset CKD. Higher Prx4 levels were significantly associated with an increased risk of CKD (hazard ratio (HR) per doubling: 1.29 [95 % confidence interval (CI): 1.21–1.37], p < 0.001), also after adjustment for risk factors including sex, smoking status, systolic blood pressure, high-sensitive C-reactive protein, chronic heart failure, diabetes mellitus and dyslipidemia (HR per doubling: 1.16 [1.06–1.24], p < 0.001). Sensitivity analyses confirmed the robustness of these findings.</div></div><div><h3>Conclusions</h3><div>This study supports the hypothesis that systemic oxidative stress, reflected by higher serum Prx4 levels, is significantly associated with the risk of developing CKD in the general population. These findings suggest that Prx4 could be a valuable biomarker for early risk stratification and prevention strategies in CKD management.</div></div>\",\"PeriodicalId\":20998,\"journal\":{\"name\":\"Redox Biology\",\"volume\":\"77 \",\"pages\":\"Article 103408\"},\"PeriodicalIF\":10.7000,\"publicationDate\":\"2024-10-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Redox Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213231724003860\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Redox Biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213231724003860","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

背景慢性肾脏病（CKD）由于在发病早期无症状，往往发现较晚。活性氧的过度产生会通过氧化应激（OS）导致各种病理过程，影响细胞结构和功能。本研究调查了血清过氧化还原酶-4（Prx4）这一氧化应激的生物标志物与普通人群中慢性肾脏病发展之间的关系。本研究的主要数据来自预防肾脏和血管疾病（PREVEND）队列，共有 5341 名基线时无慢性肾脏病的参与者接受了广泛的前瞻性健康评估。血清Prx4水平采用免疫光度测定法进行量化。主要结果是尿白蛋白排泄量 (UAE) > 30 mg/24-h、估计肾小球滤过率 (eGFR) < 60 mL/min/1.73 m2 或两者的复合值定义的新发 CKD。结果 Prx4 的基线中位数为 0.65 [四分位距（IQR）：0.42-1.04] U/L，eGFR 的中位数为 98 [IQR: 87-108] mL/min/1.73 m2，UAE 的中位数为 8.1 [IQR: 6.0-12.1] mg/L。在中位 10.4 [IQR: 6.3-11.4] 年的随访期间，867 例（16.2%）患者出现了新发 CKD。Prx4 水平越高，患 CKD 的风险越高（每增加一倍的危险比 (HR) 为 1.29 [95 % 置信区间]）：在调整了包括性别、吸烟状况、收缩压、高敏 C 反应蛋白、慢性心力衰竭、糖尿病和血脂异常在内的风险因素后，该结果仍为 1.29 [95 % 置信区间 (CI)：1.21-1.37]，p < 0.001）（每增加一倍的危险比：1.16 [1.06-1.24]，p < 0.001）。结论本研究支持这样的假设，即血清 Prx4 水平较高所反映的全身氧化应激与普通人群罹患慢性肾脏病的风险显著相关。这些研究结果表明，Prx4 可以作为一种有价值的生物标志物，用于 CKD 管理中的早期风险分层和预防策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Serum peroxiredoxin-4, a biomarker of oxidative stress, associates with new-onset chronic kidney disease: A population-based cohort study

查看原文本刊更多论文

Serum peroxiredoxin-4, a biomarker of oxidative stress, associates with new-onset chronic kidney disease: A population-based cohort study

Background

Chronic Kidney Disease (CKD), is often detected late due to its asymptomatic nature in the early stage of the disease. Overproduction of reactive oxygen species contributes to various pathological processes through oxidative stress (OS), impacting on cellular structures and functions with previous studies suggesting a link between OS and CKD progression. This study investigated the association between serum peroxiredoxin-4 (Prx4), a biomarker of oxidative stress, and the development of CKD in the general population.

Methods

This study featured data from the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) cohort, involving 5341 participants without CKD at baseline who underwent extensive prospective health evaluations. Serum Prx4 levels were quantified using an immunoluminometric assay. The primary outcome was new-onset CKD as defined by the composite of urinary albumin excretion (UAE) > 30 mg/24-h, an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m², or both.

Results

Baseline median Prx4 level was 0.65 [interquartile range (IQR): 0.42–1.04] U/L, median eGFR was 98 [IQR: 87–108] mL/min/1.73 m², and median UAE was 8.1 [IQR: 6.0–12.1] mg/L. During a median follow-up of 10.4 [IQR: 6.3–11.4] years, 867 (16.2 %) patients developed new-onset CKD. Higher Prx4 levels were significantly associated with an increased risk of CKD (hazard ratio (HR) per doubling: 1.29 [95 % confidence interval (CI): 1.21–1.37], p < 0.001), also after adjustment for risk factors including sex, smoking status, systolic blood pressure, high-sensitive C-reactive protein, chronic heart failure, diabetes mellitus and dyslipidemia (HR per doubling: 1.16 [1.06–1.24], p < 0.001). Sensitivity analyses confirmed the robustness of these findings.

Conclusions

This study supports the hypothesis that systemic oxidative stress, reflected by higher serum Prx4 levels, is significantly associated with the risk of developing CKD in the general population. These findings suggest that Prx4 could be a valuable biomarker for early risk stratification and prevention strategies in CKD management.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Redox Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

19.90

自引率

3.50%

发文量

318

审稿时长

25 days

期刊介绍： Redox Biology is the official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe. It is also affiliated with the International Society for Free Radical Research (SFRRI). This journal serves as a platform for publishing pioneering research, innovative methods, and comprehensive review articles in the field of redox biology, encompassing both health and disease. Redox Biology welcomes various forms of contributions, including research articles (short or full communications), methods, mini-reviews, and commentaries. Through its diverse range of published content, Redox Biology aims to foster advancements and insights in the understanding of redox biology and its implications.