MSOR3 演讲时间：下午 5:10

IF 1.7 4区医学 Q4 ONCOLOGY

Brachytherapy Pub Date : 2024-10-25 DOI:10.1016/j.brachy.2024.08.037

Zepaer Abudureheman MBBA , Tao Zhu MBBA , Dengyao Liu M.D., Ph.D.

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引用次数: 0

摘要

目的该研究旨在评估全身治疗和碘-125种子植入作为局部治疗手段对寡转移性非小细胞肺癌（NSCLC）患者的联合疗效，寡转移性非小细胞肺癌的定义是转移器官≤3个且转移病灶≤5个，并确定影响患者预后的因素。材料和方法对2018年1月至2023年6月在我院接受治疗的40例寡转移性NSCLC患者进行了回顾性研究。患者被分为A组（20人）和B组（20人），A组同时接受全身治疗和碘-125种子植入治疗，B组仅接受全身治疗。主要结果是无进展生存期（PFS），次要结果是总生存期（OS）。结果A组的中位无进展生存期为14.9个月（95% CI：12.8-17.0），明显长于B组的6.9个月（95% CI：4.7-9.1）（HR=6.50，95% CI：4.60-9.20）。A组的中位OS为28.7个月（95% CI：19.5-37.9），超过B组的17.0个月（95% CI：13.5-20.5）（HR=1.60，95% CI：1.05-2.40）。多变量分析强调颅内转移是影响PFS的重要风险因素。OS的影响因素包括寡转移状态、脑转移的存在、组织学亚型、免疫检查点抑制剂（ICIs）的使用、驱动基因突变、抗血管生成治疗以及局部治疗中碘-125种子植入的实施情况。这凸显了碘-125粒子植入在综合治疗策略中的价值，突出了其在提高患者生存率方面的重要作用。

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MSOR3 Presentation Time: 5:10 PM

Purpose

The study aimed to evaluate the combined efficacy of systemic therapy and iodine-125 seed implantation as a local treatment in patients with oligometastatic non-small cell lung cancer (NSCLC), defined by ≤3 metastatic organs and ≤5 metastatic lesions, and to identify factors that influence patient outcomes.

Materials and Methods

A retrospective review was conducted of 40 patients with oligometastatic NSCLC treated from January 2018 to June 2023 at our institution. Patients were divided into Group A (n=20), receiving both systemic therapy and iodine-125 seed implantation, and Group B (n=20), treated with systemic therapy alone. The primary outcome was progression-free survival (PFS), with overall survival (OS) serving as a secondary outcome. Survival analysis for PFS and OS was performed using Kaplan-Meier curves, with the Log-rank test for intergroup comparisons, and Cox regression analysis was used for univariate and multivariate analyses.

Results

The median PFS for Group A was 14.9 months (95% CI: 12.8-17.0), which was significantly longer than the 6.9 months (95% CI: 4.7-9.1) for Group B (HR=6.50, 95% CI: 4.60-9.20). The median OS was 28.7 months (95% CI: 19.5-37.9) for Group A, surpassing the 17.0 months (95% CI: 13.5-20.5) for Group B (HR=1.60, 95% CI: 1.05-2.40). Multivariate analysis highlighted intracranial metastasis as a significant risk factor for PFS. Influential factors for OS included oligometastatic status, the presence of brain metastases, histologic subtype, the use of immune checkpoint inhibitors (ICIs), driver mutations, anti-angiogenic treatments, and the implementation of iodine-125 seed implantation for local therapy.

Conclusion

In patients with oligometastatic NSCLC and stable primary lesions, the integration of systemic therapy with iodine-125 seed implantation markedly improves PFS and OS compared to systemic therapy alone. This underscores the value of iodine-125 seed implantation in the comprehensive treatment strategy, highlighting its significant role in enhancing patient survival outcomes.

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来源期刊

Brachytherapy 医学-核医学

CiteScore

3.40

自引率

21.10%

发文量

119

审稿时长

9.1 weeks

期刊介绍： Brachytherapy is an international and multidisciplinary journal that publishes original peer-reviewed articles and selected reviews on the techniques and clinical applications of interstitial and intracavitary radiation in the management of cancers. Laboratory and experimental research relevant to clinical practice is also included. Related disciplines include medical physics, medical oncology, and radiation oncology and radiology. Brachytherapy publishes technical advances, original articles, reviews, and point/counterpoint on controversial issues. Original articles that address any aspect of brachytherapy are invited. Letters to the Editor-in-Chief are encouraged.