靶向 CDK2 对抗癌症治疗中的抗药性。

IF 3 4区医学 Q2 ONCOLOGY

Future oncology Pub Date : 2024-10-29 DOI:10.1080/14796694.2024.2416382

Sara Kasirzadeh, Jimma Likisa Lenjisa, Shudong Wang

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引用次数: 0

摘要

抗药性仍然是癌症治疗的一大障碍，导致治疗失败和高死亡率。尽管治疗方法不断进步，但克服耐药性仍需要对其机制有更深入的了解。本综述强调了 CDK2 在内在和获得性耐药性中的关键作用，以及其作为治疗靶点的潜力。与 CDK2 合作的 Cyclin E 上调与各种癌症的不良预后和耐药性有关。具体来说，CCNE1/CCNE2的扩增与靶向疗法、免疫疗法、内分泌疗法和化疗/放疗的耐药性有关。鉴于 CDK2 参与了抗药性机制，研究它的作用为开发新的抗药性策略和改善治疗效果带来了希望。

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Targeting CDK2 to combat drug resistance in cancer therapy.

Drug resistance remains a major obstacle in cancer treatment, leading to treatment failures and high mortality rates. Despite advancements in therapies, overcoming resistance requires a deeper understanding of its mechanisms. This review highlights CDK2's pivotal role in both intrinsic and acquired resistance, and its potential as a therapeutic target. Cyclin E upregulation, which partners with CDK2, is linked to poor prognosis and resistance across various cancers. Specifically, amplifications of CCNE1/CCNE2 are associated with resistance to targeted therapies, immunotherapy, endocrine therapies and chemo/radiotherapy. Given CDK2's involvement in resistance mechanisms, investigating its role presents promising opportunities for developing novel strategies to combat resistance and improve treatment outcomes.

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来源期刊

Future oncology ONCOLOGY-

CiteScore

5.40

自引率

3.00%

发文量

335

审稿时长

4-8 weeks

期刊介绍： Future Oncology (ISSN 1479-6694) provides a forum for a new era of cancer care. The journal focuses on the most important advances and highlights their relevance in the clinical setting. Furthermore, Future Oncology delivers essential information in concise, at-a-glance article formats - vital in delivering information to an increasingly time-constrained community. The journal takes a forward-looking stance toward the scientific and clinical issues, together with the economic and policy issues that confront us in this new era of cancer care. The journal includes literature awareness such as the latest developments in radiotherapy and immunotherapy, concise commentary and analysis, and full review articles all of which provide key findings, translational to the clinical setting.