Hoyul Lee, Min-Ji Kim, In-Kyu Lee, Chang-Won Hong, Jae-Han Jeon
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引用次数: 0
摘要
高血糖是糖尿病和各种代谢紊乱的标志,对免疫细胞功能有着深远的影响。血糖水平升高与免疫细胞功能之间的关系是一个备受医学界关注的话题。在这篇综述中,我们旨在全面回顾高血糖对各种免疫细胞类型的影响及其临床意义,尤其是对 T 细胞、巨噬细胞、自然杀伤细胞和中性粒细胞的影响。文章旨在整合当前有关这一主题的知识,重点关注 1 型和 2 型糖尿病,以及其他需要关注高血糖的病理状态。对近期研究和临床数据进行了全面审查,以评估高血糖对免疫细胞功能的影响。有证据表明,高血糖会显著改变免疫细胞的功能,不同的糖尿病病症会表现出不同的反应。关键代谢激素在调节 T 细胞功能方面的作用凸显了恢复免疫平衡的潜在治疗目标。此外,巨噬细胞和自然杀伤细胞等先天性免疫细胞在高血糖条件下的重编程表明,代谢-免疫界面十分复杂。本综述将有助于更好地理解糖尿病、其他代谢紊乱和免疫功能之间的联系。通过研究最新的研究和临床发现,这篇综述将提高我们对作用机制的理解,并指导未来管理和治疗与高血糖相关疾病的医疗策略。
Impact of hyperglycemia on immune cell function: a comprehensive review.
Hyperglycemia, a hallmark of diabetes and various metabolic disorders, has profound implications for immune cell function. The relationship between elevated blood glucose levels and immune cell function is a topic of significant medical interest. In this review, we aim to comprehensively review effects of hyperglycemia on various immune cell types and its clinical implications, particularly T cells, macrophages, natural killer cells, and neutrophils. It aims to consolidate current knowledge on the subject, with a focus on both type 1 and type 2 diabetes, as well as other pathological states where hyperglycemia is a concern. A comprehensive examination of recent studies and clinical data was conducted to assess effects of hyperglycemia on immune cell function. Evidence indicates that hyperglycemia can significantly alter immune cell function, with different diabetic conditions showing varied responses. Roles of key metabolic hormones in regulating T cell function highlight potential therapeutic targets for restoring immune balance. In addition, reprogramming of innate immune cells such as macrophages and natural killer cells under hyperglycemic conditions suggests a complex metabolic-immunological interface. This review will contribute to a better understanding of the link between diabetes, other metabolic disorders, and immune function. By examining recent research and clinical findings, this review will enhance our comprehension of the mechanisms at play and guide future medical strategies for managing and treating conditions associated with hyperglycemia.
期刊介绍:
Diabetology International, the official journal of the Japan Diabetes Society, publishes original research articles about experimental research and clinical studies in diabetes and related areas. The journal also presents editorials, reviews, commentaries, reports of expert committees, and case reports on any aspect of diabetes. Diabetology International welcomes submissions from researchers, clinicians, and health professionals throughout the world who are interested in research, treatment, and care of patients with diabetes. All manuscripts are peer-reviewed to assure that high-quality information in the field of diabetes is made available to readers. Manuscripts are reviewed with due respect for the author''s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editors. The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.