表观遗传学酒精风险评分与血压之间的关联分析。

IF 4.8 2区 医学 Q1 GENETICS & HEREDITY
Helena Bui, Amena Keshawarz, Mengyao Wang, Mikyeong Lee, Scott M Ratliff, Lisha Lin, Kira S Birditt, Jessica D Faul, Annette Peters, Christian Gieger, Thomas Delerue, Sharon L R Kardia, Wei Zhao, Xiuqing Guo, Jie Yao, Jerome I Rotter, Yi Li, Xue Liu, Dan Liu, Juliana F Tavares, Gökhan Pehlivan, Monique M B Breteler, Irma Karabegovic, Carolina Ochoa-Rosales, Trudy Voortman, Mohsen Ghanbari, Joyce B J van Meurs, Mohamed Kamal Nasr, Marcus Dörr, Hans J Grabe, Stephanie J London, Alexander Teumer, Melanie Waldenberger, David R Weir, Jennifer A Smith, Daniel Levy, Jiantao Ma, Chunyu Liu
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引用次数: 0

摘要

背景:全表观基因组关联研究发现了多个与饮酒有关的DNA甲基化位点(CpGs),饮酒是心血管疾病的重要生活方式风险因素。本研究旨在验证饮酒表观遗传风险评分(ERS)与血压特征相关的假设:结果:我们根据先前报道的 144 个与酒精相关的 CpGs 表观遗传特征,对欧洲血统的参与者进行了荟萃分析,并在此基础上实施了表观遗传风险评分。我们发现,在多个队列中,ERS 的一个单位增量与平均每天饮用 11 杯酒有关(p 结论:ERS 的一个单位增量与平均每天饮用 11 杯酒有关:我们的研究结果表明,ERS 在评估与心血管风险有关的生活方式因素方面具有潜在的临床实用性,尤其是在自我报告的行为数据(如饮酒量)不可靠或不可用的情况下。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association analysis between an epigenetic alcohol risk score and blood pressure.

Background: Epigenome-wide association studies have identified multiple DNA methylation sites (CpGs) associated with alcohol consumption, an important lifestyle risk factor for cardiovascular diseases. This study aimed to test the hypothesis that an alcohol consumption epigenetic risk score (ERS) is associated with blood pressure (BP) traits.

Results: We implemented an ERS based on a previously reported epigenetic signature of 144 alcohol-associated CpGs in meta-analysis of participants of European ancestry. We found a one-unit increment of ERS was associated with eleven drinks of alcohol consumed per day, on average, across several cohorts (p < 0.0001). We examined the association of the ERS with systolic blood pressure (SBP), diastolic blood pressure (DBP), and hypertension (HTN) in 3,898 Framingham Heart Study (FHS) participants. Cross-sectional analyses in FHS revealed that a one-unit increment of the ERS was associated with 1.93 mm Hg higher SBP (p = 4.64E-07), 0.68 mm Hg higher DBP (p = 0.006), and an odds ratio of 1.78 for HTN (p < 2E-16). Meta-analysis of the cross-sectional association of the ERS with BP traits in eight independent external cohorts (n = 11,544) showed similar relationships with BP levels, i.e., a one-unit increase in ERS was associated with 0.74 mm Hg (p = 0.002) higher SBP and 0.50 mm Hg (p = 0.0006) higher DBP, but not with HTN. Longitudinal analyses in FHS (n = 3260) and five independent external cohorts (n = 4021) showed that the baseline ERS was not associated with a change in BP over time or with incident HTN.

Conclusions: Our findings demonstrate that the ERS has potential clinical utility in assessing lifestyle factors related to cardiovascular risk, especially when self-reported behavioral data (e.g., alcohol consumption) are unreliable or unavailable.

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来源期刊
自引率
5.30%
发文量
150
期刊介绍: Clinical Epigenetics, the official journal of the Clinical Epigenetics Society, is an open access, peer-reviewed journal that encompasses all aspects of epigenetic principles and mechanisms in relation to human disease, diagnosis and therapy. Clinical trials and research in disease model organisms are particularly welcome.
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