[m6A RNA 甲基化是治疗神经性疼痛的潜在生物靶点］

Q3 Medicine

生理学报 Pub Date : 2024-10-25

Yu-Ting Zhang, Li-Cai Zhang

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引用次数: 0

摘要

N6-甲基腺苷（m6A）是真核生物中最常见的一种RNA修饰，通过甲基转移酶、去甲基化酶和m6A结合蛋白的动态可逆调控，影响细胞内RNA代谢，控制相关病理生理过程的基因表达。近年来，m6A 甲基化参与神经病理性疼痛的研究已成为一个热门话题，一些新的认识不断涌现，m6A 甲基化已成为治疗神经病理性疼痛的潜在生物学靶点。因此，本文综述了m6A甲基化在神经病理性疼痛中的作用和调控，以期为神经病理性疼痛的药物研发和治疗提供新的启示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

[m⁶A RNA methylation is a potential biological target for neuropathic pain].

N6-methyladenosine (m⁶A) is the most common type of RNA modification in eukaryotes, which affects intracellular RNA metabolism and controls gene expression of related pathophysiological processes through dynamic reversible regulation of methyltransferases, demethylases and m⁶A-binding proteins. In recent years, the involvement of m⁶A methylation in the study of neuropathic pain has become a hot topic, some new understandings have been emerging, and m⁶A methylation has become a potential biological target for the treatment of neuropathic pain. Therefore, this article reviews the role and regulation of m⁶A methylation in neuropathic pain, in order to provide new enlightenment for the drug development and treatment of neuropathic pain.

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来源期刊

生理学报 Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

4820

期刊介绍： Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.