Whitney P. Underwood, Meghan G. Michalski, Catherine P. Lee, Gina A. Fickera, Su S. Chun, Stefan E. Eng, Lydia Y. Liu, Brandon L. Tsai, Chaya S. Moskowitz, Jessica A. Lavery, Kimberly J. Van Zee, Ginger J. Gardner, Jennifer J. Mueller, Chau T. Dang, Behfar Ehdaie, Vincent P. Laudone, James A. Eastham, Jessica M. Scott, Paul C. Boutros, Lee W. Jones
{"title":"针对癌症患者的运动疗法数字化分散试验","authors":"Whitney P. Underwood, Meghan G. Michalski, Catherine P. Lee, Gina A. Fickera, Su S. Chun, Stefan E. Eng, Lydia Y. Liu, Brandon L. Tsai, Chaya S. Moskowitz, Jessica A. Lavery, Kimberly J. Van Zee, Ginger J. Gardner, Jennifer J. Mueller, Chau T. Dang, Behfar Ehdaie, Vincent P. Laudone, James A. Eastham, Jessica M. Scott, Paul C. Boutros, Lee W. Jones","doi":"10.1038/s41746-024-01288-1","DOIUrl":null,"url":null,"abstract":"We developed and evaluated the Digital Platform for Exercise (DPEx): a decentralized, patient-centric approach designed to enhance all aspects of clinical investigation of exercise therapy. DPEx integrated provision of a treadmill with telemedicine and remote biospecimen collection permitting all study procedures to be conducted in patient’s homes. Linked health biodevices enabled high-resolution monitoring of lifestyle and physiological response. Here we describe the rationale and development of DPEx as well as feasibility evaluation in three different cohorts of patients with cancer: a phase 0a development study among three women with post-treatment primary breast cancer; a phase 0b proof-of-concept trial of neoadjuvant exercise therapy in 13 patients with untreated solid tumors; and a phase 1a level-finding trial of neoadjuvant exercise therapy in 53 men with localized prostate cancer. Collectively, our study demonstrates the utility of a fully digital, decentralized approach to conduct clinical trials of exercise therapy in a clinical population.","PeriodicalId":19349,"journal":{"name":"NPJ Digital Medicine","volume":" ","pages":"1-13"},"PeriodicalIF":12.4000,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41746-024-01288-1.pdf","citationCount":"0","resultStr":"{\"title\":\"A digital, decentralized trial of exercise therapy in patients with cancer\",\"authors\":\"Whitney P. Underwood, Meghan G. Michalski, Catherine P. Lee, Gina A. Fickera, Su S. Chun, Stefan E. Eng, Lydia Y. Liu, Brandon L. Tsai, Chaya S. Moskowitz, Jessica A. Lavery, Kimberly J. Van Zee, Ginger J. Gardner, Jennifer J. Mueller, Chau T. Dang, Behfar Ehdaie, Vincent P. Laudone, James A. Eastham, Jessica M. Scott, Paul C. Boutros, Lee W. Jones\",\"doi\":\"10.1038/s41746-024-01288-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We developed and evaluated the Digital Platform for Exercise (DPEx): a decentralized, patient-centric approach designed to enhance all aspects of clinical investigation of exercise therapy. DPEx integrated provision of a treadmill with telemedicine and remote biospecimen collection permitting all study procedures to be conducted in patient’s homes. Linked health biodevices enabled high-resolution monitoring of lifestyle and physiological response. Here we describe the rationale and development of DPEx as well as feasibility evaluation in three different cohorts of patients with cancer: a phase 0a development study among three women with post-treatment primary breast cancer; a phase 0b proof-of-concept trial of neoadjuvant exercise therapy in 13 patients with untreated solid tumors; and a phase 1a level-finding trial of neoadjuvant exercise therapy in 53 men with localized prostate cancer. Collectively, our study demonstrates the utility of a fully digital, decentralized approach to conduct clinical trials of exercise therapy in a clinical population.\",\"PeriodicalId\":19349,\"journal\":{\"name\":\"NPJ Digital Medicine\",\"volume\":\" \",\"pages\":\"1-13\"},\"PeriodicalIF\":12.4000,\"publicationDate\":\"2024-10-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.nature.com/articles/s41746-024-01288-1.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"NPJ Digital Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.nature.com/articles/s41746-024-01288-1\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"HEALTH CARE SCIENCES & SERVICES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"NPJ Digital Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41746-024-01288-1","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}
A digital, decentralized trial of exercise therapy in patients with cancer
We developed and evaluated the Digital Platform for Exercise (DPEx): a decentralized, patient-centric approach designed to enhance all aspects of clinical investigation of exercise therapy. DPEx integrated provision of a treadmill with telemedicine and remote biospecimen collection permitting all study procedures to be conducted in patient’s homes. Linked health biodevices enabled high-resolution monitoring of lifestyle and physiological response. Here we describe the rationale and development of DPEx as well as feasibility evaluation in three different cohorts of patients with cancer: a phase 0a development study among three women with post-treatment primary breast cancer; a phase 0b proof-of-concept trial of neoadjuvant exercise therapy in 13 patients with untreated solid tumors; and a phase 1a level-finding trial of neoadjuvant exercise therapy in 53 men with localized prostate cancer. Collectively, our study demonstrates the utility of a fully digital, decentralized approach to conduct clinical trials of exercise therapy in a clinical population.
期刊介绍:
npj Digital Medicine is an online open-access journal that focuses on publishing peer-reviewed research in the field of digital medicine. The journal covers various aspects of digital medicine, including the application and implementation of digital and mobile technologies in clinical settings, virtual healthcare, and the use of artificial intelligence and informatics.
The primary goal of the journal is to support innovation and the advancement of healthcare through the integration of new digital and mobile technologies. When determining if a manuscript is suitable for publication, the journal considers four important criteria: novelty, clinical relevance, scientific rigor, and digital innovation.