Pierre-Marie Faure, Agnès Tixier-Mita, Timothée Levi
{"title":"对体外心肌细胞进行实时生物仿真刺激的数字硬件系统","authors":"Pierre-Marie Faure, Agnès Tixier-Mita, Timothée Levi","doi":"10.1007/s10015-024-00968-1","DOIUrl":null,"url":null,"abstract":"<div><p>Every year, cardiovascular diseases cause millions of deaths worldwide. These diseases involve complex mechanisms that are difficult to study. To remedy this problem, we propose to develop a heart–brain platform capable of reproducing the mechanisms involved in generating the heartbeat. The platform will be designed to operate in real time, with the most economical and integrated design possible. To achieve this, we are implementing highly biologically coherent cellular models on FPGA, which we interconnect with in vitro cell cultures. In our case, we are using the Maltsev–Lakatta cell model, which describes the behavior of the pacemaker cells responsible for the heart rhythm, to stimulate a cardiomyocyte culture.</p></div>","PeriodicalId":46050,"journal":{"name":"Artificial Life and Robotics","volume":"29 4","pages":"473 - 478"},"PeriodicalIF":0.8000,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A digital hardware system for real-time biorealistic stimulation on in vitro cardiomyocytes\",\"authors\":\"Pierre-Marie Faure, Agnès Tixier-Mita, Timothée Levi\",\"doi\":\"10.1007/s10015-024-00968-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Every year, cardiovascular diseases cause millions of deaths worldwide. These diseases involve complex mechanisms that are difficult to study. To remedy this problem, we propose to develop a heart–brain platform capable of reproducing the mechanisms involved in generating the heartbeat. The platform will be designed to operate in real time, with the most economical and integrated design possible. To achieve this, we are implementing highly biologically coherent cellular models on FPGA, which we interconnect with in vitro cell cultures. In our case, we are using the Maltsev–Lakatta cell model, which describes the behavior of the pacemaker cells responsible for the heart rhythm, to stimulate a cardiomyocyte culture.</p></div>\",\"PeriodicalId\":46050,\"journal\":{\"name\":\"Artificial Life and Robotics\",\"volume\":\"29 4\",\"pages\":\"473 - 478\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2024-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Artificial Life and Robotics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10015-024-00968-1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ROBOTICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Artificial Life and Robotics","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1007/s10015-024-00968-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ROBOTICS","Score":null,"Total":0}
A digital hardware system for real-time biorealistic stimulation on in vitro cardiomyocytes
Every year, cardiovascular diseases cause millions of deaths worldwide. These diseases involve complex mechanisms that are difficult to study. To remedy this problem, we propose to develop a heart–brain platform capable of reproducing the mechanisms involved in generating the heartbeat. The platform will be designed to operate in real time, with the most economical and integrated design possible. To achieve this, we are implementing highly biologically coherent cellular models on FPGA, which we interconnect with in vitro cell cultures. In our case, we are using the Maltsev–Lakatta cell model, which describes the behavior of the pacemaker cells responsible for the heart rhythm, to stimulate a cardiomyocyte culture.