用于发育神经毒性测试的类有机物情报。

IF 4.2 3区医学 Q2 NEUROSCIENCES

Frontiers in Cellular Neuroscience Pub Date : 2024-10-08 eCollection Date: 2024-01-01 DOI:10.3389/fncel.2024.1480845

Dowlette-Mary Alam El Din, Jeongwon Shin, Alexandra Lysinger, Matthew J Roos, Erik C Johnson, Timothy J Shafer, Thomas Hartung, Lena Smirnova

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引用次数: 0

摘要

神经发育障碍的发病率越来越高，这凸显出需要改进测试方法，以确定数千种化学品的发育神经毒性（DNT）危害。本文提出将类脑智能（OI）（利用类脑器官研究体外神经可塑性）纳入 DNT 测试范例。类有机体智能为测量异种生物对可塑性机制的影响提供了一种新方法，而目前的 DNT 体外检测并未充分涵盖这一关键的生物过程。最后，人工智能（AI）技术的整合将进一步促进对复杂的类脑器官数据的分析，以研究这些可塑性机制。

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Organoid intelligence for developmental neurotoxicity testing.

The increasing prevalence of neurodevelopmental disorders has highlighted the need for improved testing methods to determine developmental neurotoxicity (DNT) hazard for thousands of chemicals. This paper proposes the integration of organoid intelligence (OI); leveraging brain organoids to study neuroplasticity in vitro, into the DNT testing paradigm. OI brings a new approach to measure the impacts of xenobiotics on plasticity mechanisms - a critical biological process that is not adequately covered in current DNT in vitro assays. Finally, the integration of artificial intelligence (AI) techniques will further facilitate the analysis of complex brain organoid data to study these plasticity mechanisms.

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来源期刊

Frontiers in Cellular Neuroscience NEUROSCIENCES-

CiteScore

7.90

自引率

3.80%

发文量

627

审稿时长

6-12 weeks

期刊介绍： Frontiers in Cellular Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the cellular mechanisms underlying cell function in the nervous system across all species. Specialty Chief Editors Egidio D‘Angelo at the University of Pavia and Christian Hansel at the University of Chicago are supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.