翻译抑制剂 Pdcd4 对耐药性的影响

IF 4.3 3区医学 Q2 CHEMISTRY, MEDICINAL

Pharmaceuticals Pub Date : 2024-10-19 DOI:10.3390/ph17101396

Qing Wang, Hsin-Sheng Yang

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引用次数: 0

摘要

程序性细胞死亡 4（Pdcd4）是一种肿瘤抑制因子，已被证实能有效抑制肿瘤发生。在生物化学上，Pdcd4 与翻译起始因子 4A 结合，抑制蛋白质翻译。除了在抑制肿瘤方面的作用外，越来越多的证据表明，Pdcd4 还能增强多种抗癌药物的化学敏感性。迄今为止，Pdcd4 的许多翻译靶点已被确定。这些靶点控制着重要的信号转导通路，削弱它们可提高化疗敏感性或克服耐药性。本综述将讨论受Pdcd4调控的信号转导途径以及Pdcd4增强化疗敏感性或对抗耐药性的潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Impact of Pdcd4, a Translation Inhibitor, on Drug Resistance.

Programmed cell death 4 (Pdcd4) is a tumor suppressor, which has been demonstrated to efficiently suppress tumorigenesis. Biochemically, Pdcd4 binds with translation initiation factor 4A and represses protein translation. Beyond its role in tumor suppression, growing evidence suggests that Pdcd4 enhances the chemosensitivity of several anticancer drugs. To date, numerous translational targets of Pdcd4 have been identified. These targets govern important signal transduction pathways, and their attenuation may improve chemosensitivity or overcome drug resistance. This review will discuss the signal transduction pathways regulated by Pdcd4 and the potential mechanisms through which Pdcd4 enhances chemosensitivity or counteracts drug resistance.

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来源期刊

Pharmaceuticals Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

6.10

自引率

4.30%

发文量

1332

审稿时长

6 weeks

期刊介绍： Pharmaceuticals (ISSN 1424-8247) is an international scientific journal of medicinal chemistry and related drug sciences.Our aim is to publish updated reviews as well as research articles with comprehensive theoretical and experimental details. Short communications are also accepted; therefore, there is no restriction on the maximum length of the papers.