美国接受奥法妥木单抗治疗的多发性硬化症患者对 COVID-19 疫苗接种的反应：病历回顾。
IF 3.9
3区 医学
Q1 CLINICAL NEUROLOGY
引用次数: 0
摘要
导言：我们需要真实世界的数据来更好地了解在接受已批准的 COVID-19 疫苗接种后，ofatumumab 对有效免疫应答能力的影响。这项回顾性真实世界分析旨在描述多发性硬化症（MS）患者在接受 ofatumumab 治疗期间对 COVID-19 疫苗接种的体液免疫反应：方法：从美国四个临床研究机构的病历中摘录了接受过COVID-19完全免疫接种的多发性硬化症患者的数据。对患者特征和体液反应进行了描述性总结。体液反应的差异根据奥妥木单抗治疗期间的疫苗接种状态（即完全接种疫苗后和加强接种疫苗后）和之前的疾病修饰治疗（DMT）暴露（即DMT新药、之前的抗CD20/磷酸肌苷[S1P]治疗、之前的非抗CD20/S1P治疗）进行记录。由于样本量有限，无法进行正式的统计分析：结果：共纳入 38 名患者。收集数据时，平均（标准偏差）的ofatumumab治疗时间为20.4（4.6）个月（35[92%]名患者正在接受治疗）。34名患者接种完全疫苗后出现明确的体液反应，其中20人（60%）血清反应呈阳性。5 名患者在加强免疫后出现了明确的体液反应，其中 3 人（60%）血清反应呈阳性。在使用ofatumumab前未接受过DMT治疗的患者中（n = 15），73%的患者血清反应呈阳性；在接受过抗CD20/S1P治疗的患者中（n = 14），33%的患者血清反应呈阳性；在接受过非抗CD20/S1P治疗的患者中（n = 9），56%的患者血清反应呈阳性。与使用DMTs的患者相比，初次使用DMT的患者确诊多发性硬化症的时间较短：结论：正在接受ofatumumab治疗的多发性硬化症患者可对COVID-19疫苗产生阳性体液反应。结论：正在接受抗CD20或S1P DMTs治疗的多发性硬化症患者可对COVID-19疫苗产生阳性体液反应。本文章由计算机程序翻译，如有差异，请以英文原文为准。
COVID-19 Vaccination Response in Patients with Multiple Sclerosis Treated with Ofatumumab in the United States: A Medical Record Review.
Introduction: Real-world data are required to provide a greater understanding of the impact of ofatumumab on the ability to mount an effective immune response following the receipt of approved COVID-19 vaccinations. This retrospective real-world analysis aimed to describe the humoral immune response to COVID-19 vaccination during ofatumumab treatment in patients with multiple sclerosis (MS).
Methods: Data from patients with MS treated with ofatumumab who were fully vaccinated against COVID-19 infection were abstracted from medical charts at four clinical sites in the USA. Patient characteristics and humoral response were summarized descriptively. Differences in humoral response were documented on the basis of vaccination status during ofatumumab treatment (i.e., after full vaccination and after booster vaccination) and prior disease-modifying treatment (DMT) exposure (i.e., DMT naïve, prior anti-CD20/sphingosine 1-phosphate [S1P] therapy, prior non-anti-CD20/S1P therapy). The sample size precluded formal statistical analysis.
Results: Thirty-eight patients were included. The mean (standard deviation) duration of ofatumumab treatment upon data collection was 20.4 (4.6) months (treatment ongoing for 35 [92%] patients). Definitive humoral response after full vaccination was documented for 34 patients, of whom 20 (60%) were seropositive. Definitive humoral response after booster vaccination was documented among five patients, of whom three (60%) were seropositive. Among patients who were DMT naïve prior to ofatumumab (n = 15), 73% were seropositive; among patients exposed to prior anti-CD20/S1P therapy (n = 14), 33% were seropositive; and among patients exposed to prior non-anti-CD20/S1P therapy (n = 9), 56% were seropositive. Patients naïve to DMT had been living with an MS diagnosis for a shorter duration than those experienced with DMTs.
Conclusion: Patients with MS receiving ongoing treatment with ofatumumab can mount a positive humoral response to a COVID-19 vaccination. Prior treatment with anti-CD20 or S1P DMTs may be a risk factor for lower humoral response.
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来源期刊
Neurology and Therapy
CLINICAL NEUROLOGY-
CiteScore
5.40
自引率
8.10%
发文量
103
审稿时长
6 weeks
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