表皮生长因子受体 2(FGFR2)在皮肤鳞状细胞癌的发生和发展中的作用

IF 3 2区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Ethan M Kallenberger, Alok Khandelwal, Priyatosh Nath, Shaun A Nguyen, John DiGiovanni, Cherie-Ann Nathan
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引用次数: 0

摘要

皮肤鳞状细胞癌(cSCC)是一种越来越常见的皮肤恶性肿瘤,也是 85 岁以上成年人死于皮肤癌的主要原因。成纤维细胞生长因子受体 2 (FGFR2) 已被确定为导致 cSCC 生长和发展的信号通路的重要作用因子。近年来,已有大量研究评估了 FGFR2 在多种癌症中的作用、它对抗癌治疗耐药性的贡献以及可用于抑制 FGFR2 的新药。本综述将概述我们目前对表皮生长因子受体 2 的了解,以及在 cSCC 中靶向表皮生长因子受体 2 的潜在机制。本综述的目标如下:(1) 强调我们目前对 FGFR2 在健康皮肤中作用的了解,并将其与在癌症发展中的作用进行对比;(2) 进一步解释 FGFR2 促进肿瘤发生的特定分子机制;(3) 描述 FGFR2 如何导致更具侵袭性的疾病;(4) 描述其在皮肤中的免疫抑制作用;(5) 评估其对当前抗癌疗法的影响,并讨论即将推出的针对 FGFR2 相关恶性肿瘤的疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
FGFR2 in the Development and Progression of Cutaneous Squamous Cell Cancer.

Cutaneous squamous cell carcinoma (cSCC) is an increasingly common malignancy of the skin and the leading cause of death from skin cancer in adults over the age of 85. Fibroblast growth factor receptor 2 (FGFR2) has been identified as an important effector of signaling pathways that lead to the growth and development of cSCC. In recent years, there have been numerous studies evaluating the role FGFR2 plays in multiple cancers, its contribution to resistance to anticancer therapy, and new drugs that may be used to inhibit FGFR2. This review will provide an overview of our current understanding of FGFR2 and potential mechanisms in which we can target FGFR2 in cSCC. The goals of this review are the following: (1) to highlight our current knowledge of the role of FGFR2 in healthy skin and contrast this with its role in the development of cancer; (2) to further explain the specific molecular mechanisms that FGFR2 uses to promote tumorigenesis; (3) to describe how FGFR2 contributes to more invasive disease; (4) to describe its immunosuppressive effects in skin; and (5) to evaluate its effect on current anticancer therapy and discuss therapies on the horizon to target FGFR2 related malignancy.

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来源期刊
Molecular Carcinogenesis
Molecular Carcinogenesis 医学-生化与分子生物学
CiteScore
7.30
自引率
2.20%
发文量
112
审稿时长
2 months
期刊介绍: Molecular Carcinogenesis publishes articles describing discoveries in basic and clinical science of the mechanisms involved in chemical-, environmental-, physical (e.g., radiation, trauma)-, infection and inflammation-associated cancer development, basic mechanisms of cancer prevention and therapy, the function of oncogenes and tumors suppressors, and the role of biomarkers for cancer risk prediction, molecular diagnosis and prognosis.
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