非 ST 段抬高型心肌梗死和复杂病变患者从症状到气球时间的影响。

IF 2.9 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Journal of Cardiovascular Medicine Pub Date : 2024-12-01 Epub Date: 2024-09-27 DOI:10.2459/JCM.0000000000001674
Yong Hoon Kim, Ae-Young Her, Seung-Woon Rha, Cheol Ung Choi, Byoung Geol Choi, Su Jin Hyun, Soohyung Park, Dong Oh Kang, Jung Rae Cho, Min-Woong Kim, Ji Young Park, Sang-Ho Park, Myung Ho Jeong
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引用次数: 0

摘要

目的:考虑到有关心电图非ST段抬高型心肌梗死(NSTEMI)患者临床预后的数据有限,本研究比较了使用新一代药物洗脱支架进行经皮冠状动脉介入治疗的患者的预后,并根据是否存在复杂病变和症状至气球时间(SBT)进行了分层:我们从韩国急性心肌梗死登记处-美国国立卫生研究院的数据集中招募了4373名NSTEMI患者,并将其分为复杂病变组(2106名患者;SBT 结果:SBT患者的全因死亡率(调整后危险比,0.656;P = 0.009)、CD(P = 0.037)和MACE(P = 0.047)以及非复杂组的卒中发生率(P = 0.020)均显著降低 结论:减少SBT可有效降低心肌梗死患者的3年死亡率:与非复合组相比,减少 SBT 可有效降低复合组 NSTEMI 患者的 3 年死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of symptom-to-balloon time in patients with non-ST-segment elevation myocardial infarction and complex lesions.

Aims: Considering the limited data regarding clinical outcomes of patients with non-ST-segment on the ECG elevation myocardial infarction (NSTEMI), this study compared the outcomes of patients undergoing percutaneous coronary intervention with newer-generation drug-eluting stents stratified by the presence/absence of complex lesions and symptom-to-balloon time (SBT; <48 h or ≥48 h).

Methods: We enrolled 4373 patients with NSTEMI from the Korea Acute Myocardial Infarction Registry-National Institute of Health dataset and stratified them into the complex group (2106 patients; SBT < 48 h, n  = 1365; SBT ≥48 h, n  = 741) and the noncomplex group (2267 patients; SBT < 48 h, n  = 1573; SBT ≥48 h, n  = 694). The primary outcome was the 3-year all-cause mortality rate. The secondary outcomes were any major adverse cardiac events (MACE), including cardiac death (CD), recurrent myocardial infarction, and stroke.

Results: The incidence of all-cause mortality (adjusted hazard ratio, 0.656; P  = 0.009), CD ( P  = 0.037), and MACE ( P  = 0.047) in the complex group and of stroke in the noncomplex group ( P  = 0.020) were significantly lower in patients with SBT < 48 h than in those with SBT ≥48 h. Among patients with SBT < 48 h, the stroke incidence ( P  = 0.019) was higher in the complex group than in the noncomplex group, while among patients with SBT ≥48 h, the MACE incidence ( P  = 0.011) was higher in the former than in the latter.

Conclusion: SBT reduction effectively decreased the 3-year mortality in patients with NSTEMI in the complex group compared with the noncomplex group.

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来源期刊
Journal of Cardiovascular Medicine
Journal of Cardiovascular Medicine 医学-心血管系统
CiteScore
3.90
自引率
26.70%
发文量
189
审稿时长
6-12 weeks
期刊介绍: Journal of Cardiovascular Medicine is a monthly publication of the Italian Federation of Cardiology. It publishes original research articles, epidemiological studies, new methodological clinical approaches, case reports, design and goals of clinical trials, review articles, points of view, editorials and Images in cardiovascular medicine. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. ​
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