探索 CHK1 在人类癌症中的致癌和免疫作用。

IF 3.3 3区 医学 Q2 ONCOLOGY
Journal of Cancer Pub Date : 2024-09-16 eCollection Date: 2024-01-01 DOI:10.7150/jca.93930
Jian Zhou, Ziyi Wu, Dilihumaer Aili, Lu Wang, Tang Liu
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引用次数: 0

摘要

背景:以前的研究表明,CHK1 对 DNA 损伤修复和细胞周期调控非常重要。目的:研究检查点激酶 1(CHK1)的表达与癌症的临床病理特征、预后和免疫浸润的关系。方法:检索多个数据库:在多个数据库中搜索相关文献并进行荟萃分析,以揭示 CHK1 与癌症临床病理特征之间的关联。利用 TIMER 和 GEPIA 数据集探讨肿瘤中 CHK1 的差异表达。采用 GEPIA 和 Kaplan-Meier Plotter 数据库检测 CHK1 在肿瘤中的预后意义。TIMER 和 cBioPortal 数据库分别用于分析免疫浸润和基因突变。结果我们发现 CHK1 的表达与低分化显著相关(OR=3.94,95% CI:2.73-5.67,PConclusions:我们的研究发现,CHK1与各种癌症的预后和免疫状态密切相关,这表明CHK1可作为癌症预后和免疫浸润的有用生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploration of the carcinogenetic and immune role of CHK1 in human cancer.

Background: Previous study indicated that CHK1 was important for repairing DNA damage and cell cycle regulation. Aims: To investigate the association of Checkpoint kinase 1 (CHK1) expression with clinicopathological features, prognosis, and immune infiltration in cancer. Methods: Several databases were searched for relevant publications to conduct a meta-analysis to reveal the association between CHK1 and clinicopathological features of cancer. TIMER and GEPIA datasets were utilized to explore the differential expression of CHK1 of tumors. GEPIA and Kaplan-Meier Plotter databases were adopted to detect the prognostic significance of CHK1 in tumor. TIMER and cBioPortal databases were used for the analysis regarding immune infiltration and mutation respectively. Results: We found that CHK1 expression was significantly associated with low differentiation (OR=3.94, 95% CI: 2.73-5.67, P<0.05), advanced stage (OR=3.20, 95% CI: 2.30-4.44, P<0.05), vascular infiltration (OR=3.24, 95% CI: 2.18-4.82, P<0.05) and lymph node metastasis (OR=3.55, 95% CI: 2.62-4.82, P<0.05) of various cancers. CHK1 was highly expressed in multiple cancers and was related to clinical stage, survival, immune infiltration in pan-cancers. Conclusions: Our study found that CHK1 was significantly related to prognosis and immunological status in various cancers, suggesting that CHK1 may serve as a useful biomarker for prognosis and immune infiltration in cancer.

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来源期刊
Journal of Cancer
Journal of Cancer ONCOLOGY-
CiteScore
8.10
自引率
2.60%
发文量
333
审稿时长
12 weeks
期刊介绍: Journal of Cancer is an open access, peer-reviewed journal with broad scope covering all areas of cancer research, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer. The Journal is supported by an international editorial board consisting of a distinguished team of cancer researchers. Journal of Cancer aims at rapid publication of high quality results in cancer research while maintaining rigorous peer-review process.
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