怪物的逻辑:基于干细胞的胚胎模型的发育和形态多样性。

IF 3.6 3区 生物学 Q1 BIOLOGY
Interface Focus Pub Date : 2024-10-25 eCollection Date: 2024-10-11 DOI:10.1098/rsfs.2024.0023
Dominica Cao, Sumit Garai, James DiFrisco, Jesse V Veenvliet
{"title":"怪物的逻辑:基于干细胞的胚胎模型的发育和形态多样性。","authors":"Dominica Cao, Sumit Garai, James DiFrisco, Jesse V Veenvliet","doi":"10.1098/rsfs.2024.0023","DOIUrl":null,"url":null,"abstract":"<p><p>Organoids and stem-cell-based embryo models (SEMs) are imperfect organ or embryo representations that explore a much larger space of possible forms, or morphospace, compared to their <i>in vivo</i> counterparts. Here, we discuss SEM biology in light of seminal work by Pere Alberch, a leading figure in early evo-devo, interpreting SEMs as developmental 'monstrosities' in the Alberchian sense. Alberch suggested that ordered patterns in aberrant development-i.e. 'the logic of monsters'-reveal developmental constraints on possible morphologies. In the same vein, we detail how SEMs have begun to shed light on structural features of normal development, such as developmental variability, the relative importance of internal versus external constraints, boundary conditions and design principles governing robustness and canalization. We argue that SEMs represent a powerful experimental tool to explore and expand developmental morphospace and propose that the 'monstrosity' of SEMs can be leveraged to uncover the 'hidden' rules and developmental constraints that robustly shape and pattern the embryo.</p>","PeriodicalId":13795,"journal":{"name":"Interface Focus","volume":null,"pages":null},"PeriodicalIF":3.6000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503023/pdf/","citationCount":"0","resultStr":"{\"title\":\"The logic of monsters: development and morphological diversity in stem-cell-based embryo models.\",\"authors\":\"Dominica Cao, Sumit Garai, James DiFrisco, Jesse V Veenvliet\",\"doi\":\"10.1098/rsfs.2024.0023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Organoids and stem-cell-based embryo models (SEMs) are imperfect organ or embryo representations that explore a much larger space of possible forms, or morphospace, compared to their <i>in vivo</i> counterparts. Here, we discuss SEM biology in light of seminal work by Pere Alberch, a leading figure in early evo-devo, interpreting SEMs as developmental 'monstrosities' in the Alberchian sense. Alberch suggested that ordered patterns in aberrant development-i.e. 'the logic of monsters'-reveal developmental constraints on possible morphologies. In the same vein, we detail how SEMs have begun to shed light on structural features of normal development, such as developmental variability, the relative importance of internal versus external constraints, boundary conditions and design principles governing robustness and canalization. We argue that SEMs represent a powerful experimental tool to explore and expand developmental morphospace and propose that the 'monstrosity' of SEMs can be leveraged to uncover the 'hidden' rules and developmental constraints that robustly shape and pattern the embryo.</p>\",\"PeriodicalId\":13795,\"journal\":{\"name\":\"Interface Focus\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2024-10-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503023/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Interface Focus\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1098/rsfs.2024.0023\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/10/11 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Interface Focus","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1098/rsfs.2024.0023","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/11 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

器官组织和基于干细胞的胚胎模型(SEM)是一种不完美的器官或胚胎表征,与体内模型相比,它们探索了更大的可能形式空间或形态空间。在此,我们将根据早期进化-胚胎学领军人物佩雷-阿尔伯奇(Pere Alberch)的开创性工作来讨论SEM生物学,将SEM解释为阿尔伯奇意义上的发育 "怪胎"。阿尔伯奇认为,异常发育中的有序模式--即 "怪物的逻辑"--揭示了可能形态的发育限制。同样,我们详细介绍了扫描电子显微镜如何开始揭示正常发育的结构特征,如发育的可变性、内部与外部约束的相对重要性、边界条件以及稳健性和管道化的设计原则。我们认为,扫描电子显微镜是探索和扩展发育形态空间的强大实验工具,并提出可以利用扫描电子显微镜的 "畸形 "来揭示 "隐藏 "的规则和发育约束,这些规则和约束有力地塑造了胚胎的形态和模式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The logic of monsters: development and morphological diversity in stem-cell-based embryo models.

Organoids and stem-cell-based embryo models (SEMs) are imperfect organ or embryo representations that explore a much larger space of possible forms, or morphospace, compared to their in vivo counterparts. Here, we discuss SEM biology in light of seminal work by Pere Alberch, a leading figure in early evo-devo, interpreting SEMs as developmental 'monstrosities' in the Alberchian sense. Alberch suggested that ordered patterns in aberrant development-i.e. 'the logic of monsters'-reveal developmental constraints on possible morphologies. In the same vein, we detail how SEMs have begun to shed light on structural features of normal development, such as developmental variability, the relative importance of internal versus external constraints, boundary conditions and design principles governing robustness and canalization. We argue that SEMs represent a powerful experimental tool to explore and expand developmental morphospace and propose that the 'monstrosity' of SEMs can be leveraged to uncover the 'hidden' rules and developmental constraints that robustly shape and pattern the embryo.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Interface Focus
Interface Focus BIOLOGY-
CiteScore
9.20
自引率
0.00%
发文量
44
审稿时长
6-12 weeks
期刊介绍: Each Interface Focus themed issue is devoted to a particular subject at the interface of the physical and life sciences. Formed of high-quality articles, they aim to facilitate cross-disciplinary research across this traditional divide by acting as a forum accessible to all. Topics may be newly emerging areas of research or dynamic aspects of more established fields. Organisers of each Interface Focus are strongly encouraged to contextualise the journal within their chosen subject.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信