Lin Su, Jiawen Bu, Jiahui Yu, Mila Jin, Guanliang Meng, Xudong Zhu
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It also explores the role of DNA methylation in regulating HCC's malignant progression and sorafenib resistance, alongside elaborating the therapeutic effects of DNA methyltransferase inhibitors on HCC. 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引用次数: 0
摘要
肝细胞癌（HCC）是一种原发性恶性肿瘤，在全球死亡率中排名第二，对健康构成重大威胁。表观遗传学改变，尤其是 DNA 甲基化，已成为与 HCC 诊断、治疗、预后和恶性进展相关的关键因素。然而，目前仍缺乏对驱动 HCC 进展的 DNA 甲基化机制及其作为治疗生物标记物潜力的全面分析。本综述试图全面总结 DNA 甲基化的各个方面，如其机制、检测方法以及有助于 HCC 诊断、治疗和预后评估的生物标志物。它还探讨了 DNA 甲基化在调控 HCC 恶性进展和索拉非尼耐药性方面的作用，同时阐述了 DNA 甲基转移酶抑制剂对 HCC 的治疗效果。对这些方面的详细研究强调了对肿瘤细胞中DNA甲基化的重要研究，这些研究旨在阐明恶性进展机制、确定诊断标志物以及开发治疗HCC的新型肿瘤特异性抑制剂。要点：全面总结 DNA 甲基化的各个方面，如其机制、检测方法以及有助于诊断和治疗的生物标志物。DNA 甲基化在调控肝细胞癌（HCC）恶性进展和索拉非尼耐药性中的作用，同时阐述 DNA 甲基转移酶抑制剂的治疗效果。深入研究 DNA 甲基化对发现治疗 HCC 的新型肿瘤特异性抑制剂至关重要。
Comprehensive review and updated analysis of DNA methylation in hepatocellular carcinoma: From basic research to clinical application
Hepatocellular carcinoma (HCC) is a primary malignant tumour, ranking second in global mortality rates and posing significant health threats. Epigenetic alterations, particularly DNA methylation, have emerged as pivotal factors associated with HCC diagnosis, therapy, prognosis and malignant progression. However, a comprehensive analysis of the DNA methylation mechanism driving HCC progression and its potential as a therapeutic biomarker remains lacking. This review attempts to comprehensively summarise various aspects of DNA methylation, such as its mechanism, detection methods and biomarkers aiding in HCC diagnosis, treatment and prognostic assessment of HCC. It also explores the role of DNA methylation in regulating HCC's malignant progression and sorafenib resistance, alongside elaborating the therapeutic effects of DNA methyltransferase inhibitors on HCC. A detailed examination of these aspects underscores the significant research on DNA methylation in tumour cells to elucidate malignant progression mechanisms, identify diagnostic markers and develop new tumour-specific inhibitors for HCC.
Key points
A comprehensive summary of various aspects of DNA methylation, such as its mechanism, detection methods and biomarkers aiding in diagnosis and treatment.
The role of DNA methylation in regulating hepatocellular carcinoma's (HCC) malignant progression and sorafenib resistance, alongside elaborating therapeutic effects of DNA methyltransferase inhibitors.
Deep research on DNA methylation is critical for discovering novel tumour-specific inhibitors for HCC.
期刊介绍：
Clinical and Translational Medicine (CTM) is an international, peer-reviewed, open-access journal dedicated to accelerating the translation of preclinical research into clinical applications and fostering communication between basic and clinical scientists. It highlights the clinical potential and application of various fields including biotechnologies, biomaterials, bioengineering, biomarkers, molecular medicine, omics science, bioinformatics, immunology, molecular imaging, drug discovery, regulation, and health policy. With a focus on the bench-to-bedside approach, CTM prioritizes studies and clinical observations that generate hypotheses relevant to patients and diseases, guiding investigations in cellular and molecular medicine. The journal encourages submissions from clinicians, researchers, policymakers, and industry professionals.
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