Lin Li, Rui Li, Qingying Tian, Yaogan Luo, Ruyi Li, Xiaoyu Lin, Yunjing Ou, Tianyu Guo, Xue Chen, An Pan, JoAnn E Manson, Gang Liu
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引用次数: 0
摘要
除热量限制外,健康低碳水化合物饮食(HLCD)和限时进食(TRE)单独或联合使用对体重和肠道微生物组的影响仍不清楚。在这项为期 12 周、随访 28 周的两两因子随机试验中,96 名超重或肥胖参与者的等热量限食效果显著,各组体重减轻 2.57 至 4.11 千克不等。除热量限制外,HLCD 和 TRE 还能进一步降低体重指数。HLCD 导致更多的脂肪减少,而 TRE 则导致更多的瘦肉减少。此外,HLCD 会导致粪便中支链氨基酸的减少,而 TRE 则会增加参与合成短链脂肪酸的益生菌种类。此外,HLCD 在减少脂肪量方面的效果在干预后的随访中得以持续。总之,HLCD 和 TRE 能有效控制体重,并在热量限制之外产生深远的肠道微生物组和代谢组改变。本研究已在ChiCTR.org.cn注册(ChiCTR2200056363)。
Effects of healthy low-carbohydrate diet and time-restricted eating on weight and gut microbiome in adults with overweight or obesity: Feeding RCT.
The effect of a healthy low-carbohydrate diet (HLCD) and time-restricted eating (TRE), alone or in combination, on body weight and gut microbiome beyond caloric restriction remains unclear. In this 12-week two-by-two factorial randomized trial with a 28-week follow-up among 96 participants with overweight or obesity, isocaloric-restricted feeding yields significant weight loss, ranging from 2.57 to 4.11 kg across different groups. Beyond caloric restriction, HLCD and TRE lead to additional reduction in body mass index. HLCD results in additional fat mass loss while TRE yields more lean mass loss. Additionally, HLCD leads to decreased fecal branched-chain amino acids, and TRE tends to yield an increased abundance of probiotic species involved in synthesizing short-chain fatty acids. Moreover, the effect of HLCD on reducing fat mass is sustained during the post-intervention follow-up. Overall, HLCD and TRE are effective in weight management and yield profound gut microbiome and metabolome alteration beyond caloric restriction. This study was registered at ChiCTR.org.cn (ChiCTR2200056363).
Cell Reports MedicineBiochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
15.00
自引率
1.40%
发文量
231
审稿时长
40 days
期刊介绍:
Cell Reports Medicine is an esteemed open-access journal by Cell Press that publishes groundbreaking research in translational and clinical biomedical sciences, influencing human health and medicine.
Our journal ensures wide visibility and accessibility, reaching scientists and clinicians across various medical disciplines. We publish original research that spans from intriguing human biology concepts to all aspects of clinical work. We encourage submissions that introduce innovative ideas, forging new paths in clinical research and practice. We also welcome studies that provide vital information, enhancing our understanding of current standards of care in diagnosis, treatment, and prognosis. This encompasses translational studies, clinical trials (including long-term follow-ups), genomics, biomarker discovery, and technological advancements that contribute to diagnostics, treatment, and healthcare. Additionally, studies based on vertebrate model organisms are within the scope of the journal, as long as they directly relate to human health and disease.