经皮椎体后凸成形术局部麻醉中使用利多卡因联合艾司卡胺可改善老年患者的疼痛:一项随机对照研究。

IF 2.3 3区 医学 Q2 ANESTHESIOLOGY
Longyuan Zhou, Lei Lv, Ruilan Wu, Wenbo Mang, Lihong Hu
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引用次数: 0

摘要

背景:在局部麻醉下进行经皮椎体成形术时,老年患者往往会感到剧烈疼痛。本研究旨在评估利多卡因联合艾司卡胺对通过经皮椎体后凸成形术接受局部麻醉的老年患者疼痛改善情况的影响:这项前瞻性随机比较试验的对象是在局部麻醉下接受单层腰椎经皮椎体后凸成形术的66名老年患者,年龄在60-80岁之间,美国麻醉医师协会(ASA)分级为I-III级、I-III级,体重指数(BMI)为18.5-25 kg/m2。患者被平均分为两组(每组 33 人)。LE组接受200毫克1%利多卡因和25毫克艾司卡胺(总量20毫升),L组接受200毫克1%利多卡因(总量20毫升)。比较了各组患者的特征、手术情况、VAS评分、MAP、HR、MOAA/S评分、患者满意度和相关不良反应。术中和术后的 VAS 评分被视为主要结果:两组患者在以下时间点的 VAS 评分差异有统计学意义:穿刺针建立通道、球囊扩张、骨水泥注射和术后(P=0.05):在老年患者局部经皮椎体后凸成形术中应用利多卡因联合艾司卡胺,不仅能起到有效的镇痛效果,还能提高手术安全性和患者舒适度,对促进老年患者手术麻醉管理的优化具有重要的临床价值:该研究于2023年12月6日在Chictr.org.cn注册,注册号为ChiCTR2400083466。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Improvement in pain by using lidocaine combined with esketamine in elderly patients receiving local anaesthesia for percutaneous kyphoplasty: a randomized controlled study.

Background: Elderly patients often experience severe pain during percutaneous kyphoplasty under local anaesthesia. The aim of this work was to evaluate the effect of lidocaine combined with esketamine on pain improvement in elderly patients receiving local anaesthesia via percutaneous kyphoplasty.

Methods: This prospective, randomized comparative trial was conducted on 66 elderly patients, aged 60-80 years, with an American Society of Anaesthesiologists (ASA) grade of I-III, I‒III and a BMI of 18.5-25 kg/m2, who underwent single-level lumbar percutaneous kyphoplasty under local anaesthesia. Patients were divided into two equal groups (33 per group). Group LE received 200 mg of 1% lidocaine and 25 mg of esketamine (total volume of 20 ml), and Group L received 200 mg of 1% lidocaine (total volume of 20 ml). Patient characteristics, surgery, VAS scores, MAP, HR, MOAA/S scores, patient satisfaction and related adverse reactions were compared for the groups. The VAS scores during and after surgery were considered the primary outcome.

Results: There were statistically significant differences in the VAS score between the two groups at the following time points: channel establishment by the puncture needle, balloon dilation, bone cement injection and postoperative period (P < 0.05). The VAS score decreased in the LE group, but the MAP and HR were more stable, and the difference was statistically significant (P < 0.05). The difference in the MOAA/S score between the two groups was statistically significant (P < 0.05), and the MOAA/S score in the LE group decreased. The patient satisfaction level in the LE group was 100% and 48.48% in the L group (P < 0.05). There were no related complications or adverse reactions in either group.

Conclusion: The application of lidocaine combined with esketamine in local episcopal percutaneous vertebral kyphoplasty in elderly patients not only provides an effective analgesic effect but also improves surgical safety and patient comfort, which has important clinical value in promoting the optimization of surgical anaesthesia management in elderly patients.

Trial registration: The study was registered at Chictr.org.cn with the number ChiCTR2400083466 on 06/12/2023.

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来源期刊
BMC Anesthesiology
BMC Anesthesiology ANESTHESIOLOGY-
CiteScore
3.50
自引率
4.50%
发文量
349
审稿时长
>12 weeks
期刊介绍: BMC Anesthesiology is an open access, peer-reviewed journal that considers articles on all aspects of anesthesiology, critical care, perioperative care and pain management, including clinical and experimental research into anesthetic mechanisms, administration and efficacy, technology and monitoring, and associated economic issues.
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