从 COVID-19 大流行看再生障碍性贫血：感染、疫苗接种和病理生理机制。

IF 3 3区医学 Q2 HEMATOLOGY

Annals of Hematology Pub Date : 2024-10-23 DOI:10.1007/s00277-024-06052-9

Nelson Luis Cahuapaza-Gutierrez

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引用次数: 0

摘要

感染 SARS-CoV-2 并接种 COVID-19 疫苗的患者可能会出现再生障碍性贫血（AA）。通过在 PubMed、Scopus、EMBASE 和 Web of Science 中进行选择性文献检索，对研究进行了全面回顾和分析。本次分析共纳入 26 项研究，包括 16 个病例报告、7 个系列病例和 3 个观察性研究，共计 53 名患者。获得性或特发性 AA 的病因多种多样；本综述介绍了最近的研究结果，包括可能的新病因，如 SARS-CoV-2 感染和 COVID-19 疫苗。本文探讨了这种可能的关联，填补了现有的空白，旨在改善日常医疗实践。本文回顾了 AA 与 SARS-CoV-2 感染以及 COVID-19 疫苗之间的关系，分析了 AA 的新发病例和复发病例。虽然尚未确定两者之间的确切联系，但本文探讨了可能的潜在病理生理机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Aplastic Anemia in the light of the COVID-19 pandemic: infection, vaccination, and pathophysiologic mechanisms.

Patients infected with SARS-CoV-2 and vaccinated against COVID-19 could develop aplastic anemia (AA). Comprehensive review and analysis were conducted through a selective literature search in PubMed, Scopus, EMBASE, and Web of Science. For this analysis, 26 studies were included, comprising 16 case reports, 7 case series, and 3 observational studies, totaling 53 patients. The causes of acquired or idiopathic AA are diverse; this review presents recent findings, including possible new etiologies such as SARS-CoV-2 infection and COVID-19 vaccines. This possible association is explored, addressing the existing gap, and aiming to improve daily medical practice. This article reviews the relationship between AA and SARS-CoV-2 infection, as well as COVID-19 vaccines, analyzing cases of de novo occurrence and relapses of AA. Although a definitive mechanistic link has not yet been established, possible underlying pathophysiological mechanisms are explored.

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来源期刊

Annals of Hematology 医学-血液学

CiteScore

5.60

自引率

2.90%

发文量

304

审稿时长

2 months

期刊介绍： Annals of Hematology covers the whole spectrum of clinical and experimental hematology, hemostaseology, blood transfusion, and related aspects of medical oncology, including diagnosis and treatment of leukemias, lymphatic neoplasias and solid tumors, and transplantation of hematopoietic stem cells. Coverage includes general aspects of oncology, molecular biology and immunology as pertinent to problems of human blood disease. The journal is associated with the German Society for Hematology and Medical Oncology, and the Austrian Society for Hematology and Oncology.