Tahagod Mohamed, Robin Alexander, Brielle Davidson, Brett Klamer, Alison Gehred, Michelle C Starr, Cara Slagle, Catherine Krawczeski, Matthew W Harer
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引用次数: 0
摘要
目的：急性肾损伤（AKI）是住院早产新生儿的常见病。尿液中性粒细胞明胶酶相关脂质体蛋白（uNGAL）是一种很有前景的非侵入性 AKI 生物标志物。然而，没有发生 AKI 的早产新生儿尿液中中性粒细胞明胶酶相关脂质钙蛋白的正常值还不太清楚。本研究旨在评估现有文献，以确定无 AKI 早产新生儿的 uNGAL 正常值：研究设计：对 2021 年 11 月之前发表的所有评估无 AKI 早产新生儿尿蛋白（uNGAL）值的文章进行系统回顾和荟萃分析：早产新生儿的uNGAL值更高 结论：在有限的研究中，早产新生儿的uNGAL值范围广泛：在有限的研究中，无 AKI 早产新生儿的 uNGAL 值范围很广。未来的研究应使用更大的队列（按性别和出生体重）来确定早产新生儿的正常尿NGAL值：- 要点：尿NGAL是新生儿AKI的一种有希望的无创生物标记物。- 据报道，早产新生儿的尿NGAL值范围很广，但基线值并不明确。- 与早产儿相比，极早产儿的尿液NGAL值更高。
Urinary Neutrophil Gelatinase-Associated Lipocalin Values in Preterm Neonates: A Systematic Review and Meta-analysis.
Objective: Acute kidney injury (AKI) is common in hospitalized preterm neonates. Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is a promising noninvasive AKI biomarker. However, normal values of uNGAL in preterm neonates without AKI are poorly characterized. The objective of this study was to evaluate the current literature to determine normal uNGAL values for preterm neonates without AKI.
Study design: Systematic review and meta-analysis of all articles published before November 2021 evaluating uNGAL values in preterm neonates without AKI.
Results: Of 1,607 studies evaluated for eligibility, 11 were included in the final meta-analysis (210 males, 202 females). uNGAL values were higher in the preterm neonates <29 weeks and ranged between 20.7 and 782.65 ng/mL. Meta mean estimates of gestational age (GA), birthweight, and neutrophil gelatinase-associated lipocalin were 29.4 weeks (95% confidence interval [CI]: 28.8-30.0), 1,241 g (95% CI: 1,111-1,372), and 148.9 ng/mL (95% CI: 48-231), respectively.
Conclusion: In limited studies, a wide range of uNGAL values in preterm neonates without AKI are reported. Future studies should identify normal uNGAL values in preterm neonates using larger cohorts by GA and birthweight.
Key points: · Urinary NGAL is a promising noninvasive biomarker of neonatal AKI.. · A wide range of uNGAL is reported in preterm neonates but the baseline values are not well defined.. · Urine NGAL values are higher in extremely preterm compared with preterm neonates..
期刊介绍：
The American Journal of Perinatology is an international, peer-reviewed, and indexed journal publishing 14 issues a year dealing with original research and topical reviews. It is the definitive forum for specialists in obstetrics, neonatology, perinatology, and maternal/fetal medicine, with emphasis on bridging the different fields.
The focus is primarily on clinical and translational research, clinical and technical advances in diagnosis, monitoring, and treatment as well as evidence-based reviews. Topics of interest include epidemiology, diagnosis, prevention, and management of maternal, fetal, and neonatal diseases. Manuscripts on new technology, NICU set-ups, and nursing topics are published to provide a broad survey of important issues in this field.
All articles undergo rigorous peer review, with web-based submission, expedited turn-around, and availability of electronic publication.
The American Journal of Perinatology is accompanied by AJP Reports - an Open Access journal for case reports in neonatology and maternal/fetal medicine.
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