环孢素诱发糖尿。

Skinmed Pub Date : 2024-10-22 eCollection Date: 2024-01-01
Heng Li Wei, Ho Sheun Ling Madeline, Yew Yik Weng
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引用次数: 0

摘要

我们的第一位患者是一名 42 岁的健康中国男子,患有中重度银屑病,外用强效类固醇激素和维生素 D 类似物也未能充分控制病情。他使用免疫抑制剂前的检查结果正常。在改用环孢素之前,他服用了甲氨蝶呤,初始剂量为每天 200 毫克(2.44 毫克/千克/天)。开始使用环孢素两个月后,他的尿检结果正常。环孢素治疗 18 个月后,尽管他的空腹血清葡萄糖为 5.2 mmol/L(正常),而且没有任何尿路感染(UTI)的迹象,但他的尿检却发现了糖尿(300 mg/dL)。这种情况是在每两天服用 100 毫克(0.610 毫克/千克/天)的剂量下出现的。下次检查时,糖尿症状消失,他转而使用阿达木单抗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cyclosporine-Iinduced Glycosuria.

Our first patient was a 42-year-old healthy Chinese man with moderately severe psoriasis, not adequately controlled with potent topical steroids and vitamin D analogs. His pre-immunosuppressant work-up was normal. He was prescribed methotrexate prior to switching to cyclosporine with an initial dose of 200 mg daily (2.44 mg/kg/day). His urinalysis was normal 2 months after initiating cyclosporine. After 18 months of cyclosporine therapy, his urinalysis revealed glycosuria (300 mg/dL), even though his fasting serum glucose was 5.2 mmol/L (normal) and there was no indication of any urinary tract infection (UTI). This occurred at a dose of 100 mg every 2 days (0.610 mg/kg/day). The glycosuria resolved on the next check, and he was shifted to adalimumab.

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