心肺康复计划对突尼斯长COVID19患者亚极限运动的影响:随机临床试验。

IF 4.2 2区 医学 Q1 SPORT SCIENCES
Biology of Sport Pub Date : 2024-10-01 Epub Date: 2024-04-25 DOI:10.5114/biolsport.2024.139072
Rania Kaddoussi, Hadhemi Rejeb, Amine Kalai, Eya Zaara, Naceur Rouetbi, Zohra Ben Salah Frih, Piotr Zmijewski, Helmi Ben Saad
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引用次数: 0

摘要

目前还缺乏随机临床试验(RCT)来探讨心肺康复计划(CPRP)对长COVID-19患者(LC19Ps)亚极限有氧能力的影响。本研究旨在评估非卧床 CPRP 对 LC19Ps 的 6 分钟步行测试(6MWT)数据(主要结果:6 分钟步行距离(6MWD))的影响。该研究以单盲 RCT 的形式进行,纳入了确诊后至少三个月出现持续性呼吸困难(即修正医学研究委员会 (mMRC) 级别≥2)的突尼斯 LC19 患者。LC19Ps 被随机分配到干预组(IG,n = 20)或对照组(CG,n = 10)。CPRP前后的评估包括呼吸困难评估(Borg和mMRC量表)、人体测量数据、肺活量测定和6MWT。心肺复苏术(即在六周内进行 18 次训练)包括热身、有氧训练、阻力训练、呼吸练习和治疗教育。CPRP 明显改善了 i) 呼吸困难,即与 CG 相比,IG 在 Borg(-3.5 ± 2.0 vs. -1.3 ± 1.5)和 mMRC(-1.5 ± 0.8 vs. -0.1 ± 0.3)量表上的下降幅度更大;以及 ii) 6MWD,即与 CG 相比,IG 在 6MWD 上的下降幅度更大。与 CG 相比,IG 在 6MWD(米,%)(分别为 168 ± 99 对 5 ± 45 米,28 ± 8 对 1 ± 8%)和静息心率(bpm,最大预测心率的百分比)(分别为 -9 ± 9 对 1 ± 7 bpm;-5 ± 6 对 0 ± 4%)方面的改善幅度更大,但影响大小较小。在 IG 中,mMRC 下降了 1.5 分,6MWD 增加了 168 米,分别超过了建议的最小临床重要差异 1 分和 30 米。CPRP似乎能有效提高LC19Ps的亚极限运动能力,尤其是在改善6MWD、呼吸困难和静息心率方面。RCT 注册:www.pactr.org;PACTR202303849880222。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of a cardiopulmonary rehabilitation programme on submaximal exercise in Tunisian patients with long-COVID19: A randomized clinical trial.

There is a lack of randomized clinical trials (RCTs) exploring the outcomes of cardiopulmonary rehabilitation programmes (CPRPs) on submaximal aerobic capacity of long COVID-19 patients (LC19Ps). This RCT aimed to evaluate the effect of an ambulatory CPRP on the 6-min walk test (6MWT) data (main outcome: 6-min walk distance (6MWD)) of LC19Ps. Conducted as a single-blinded RCT, the study included Tunisian LC19Ps with persistent dyspnoea (i.e. modified medical research council (mMRC) level ≥2) at least three months postdiagnosis. LC19Ps were randomly assigned to the intervention (IG, n = 20) or control (CG, n = 10) groups. Pre- and post-CPRP evaluations included dyspnoea assessments (Borg and mMRC scales), anthropometric data, spirometry, and 6MWT. The CPRP (i.e. 18 sessions over six weeks) encompassed warm-up, aerobic training, resistance training, respiratory exercises, and therapeutic education. The CPRP significantly improved i) dyspnoea, i.e. IG exhibited larger reductions compared to the CG in Borg (-3.5 ± 2.0 vs. -1.3 ± 1.5) and mMRC (-1.5 ± 0.8 vs. -0.1 ± 0.3) scales, and ii) 6MWD, i.e. IG demonstrated larger improvements compared to the CG in 6MWD (m, %) (168 ± 99 vs. 5 ± 45 m, 28 ± 8 vs. 1 ± 8%, respectively), and resting heart rate (bpm, % maximal predicted heart rate) (-9 ± 9 vs. 1 ± 7 bpm; -5 ± 6 vs. 0 ± 4%, respectively), with small effect sizes. In the IG, the 1.5-point decrease in mMRC and the 168 m increase in 6MWD exceeded the recommended minimal clinical important differences of 1 point and 30 m, respectively. CPRP appears to be effective in enhancing the submaximal exercise capacity of LC19Ps, particularly in improving 6MWD, dyspnoea, and resting heart rate. RCT registration: www.pactr.org; PACTR202303849880222.

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来源期刊
Biology of Sport
Biology of Sport 生物-运动科学
CiteScore
8.20
自引率
12.50%
发文量
113
审稿时长
>12 weeks
期刊介绍: Biology of Sport is the official journal of the Institute of Sport in Warsaw, Poland, published since 1984. Biology of Sport is an international scientific peer-reviewed journal, published quarterly in both paper and electronic format. The journal publishes articles concerning basic and applied sciences in sport: sports and exercise physiology, sports immunology and medicine, sports genetics, training and testing, pharmacology, as well as in other biological aspects related to sport. Priority is given to inter-disciplinary papers.
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