片上癌症:用于癌细胞建模的突破性片上器官技术。

IF 2.6 4区 医学 Q2 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS
Babak Nejati, Reza Shahhosseini, Mobasher Hajiabbasi, Nastaran Safavi Ardabili, Kosar Bagtashi Baktash, Vahid Alivirdiloo, Sadegh Moradi, Mohammadreza Farhadi Rad, Fatemeh Rahimi, Marzieh Ramezani Farani, Farhood Ghazi, Ahmad Mobed, Iraj Alipourfard
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引用次数: 0

摘要

癌症仍然是导致全球死亡的主要原因之一。由于肿瘤的分子机制不明确,体内微环境复杂,因此很难弄清癌症的本质,也很难开发出有效的治疗方法。因此,开发有效治疗癌症的新方法迫在眉睫,意义重大。芯片上器官(OoC)系统可能是制药业为解决日益增长的研发成本而寻求的突破性技术。过去十年中,与 OoC 技术相关的癌症疗法空间建模取得了重大进展,改善了生理暴露标准。本文旨在总结利用 OoC 技术在三维微环境中模拟癌细胞治疗的最新成果和研究成果。为此,我们将首先详细讨论 OoC 系统,然后展示 Ooc 癌细胞治疗研究的最新成果,以及该技术如何潜在地优化更好的肿瘤建模。本研究还将讨论 OoC 系统在治疗癌细胞方面的前景及其优势和局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cancer-on-chip: a breakthrough organ-on-a-chip technology in cancer cell modeling.

Cancer remains one of the leading causes of death worldwide. The unclear molecular mechanisms and complex in vivo microenvironment of tumors make it difficult to clarify the nature of cancer and develop effective treatments. Therefore, the development of new methods to effectively treat cancer is urgently needed and of great importance. Organ-on-a-chip (OoC) systems could be the breakthrough technology sought by the pharmaceutical industry to address ever-increasing research and development costs. The past decade has seen significant advances in the spatial modeling of cancer therapeutics related to OoC technology, improving physiological exposition criteria. This article aims to summarize the latest achievements and research results of cancer cell treatment simulated in a 3D microenvironment using OoC technology. To this end, we will first discuss the OoC system in detail and then demonstrate the latest findings of the cancer cell treatment study by Ooc and how this technique can potentially optimize better modeling of the tumor. The prospects of OoC systems in the treatment of cancer cells and their advantages and limitations are also among the other points discussed in this study.

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来源期刊
Medical & Biological Engineering & Computing
Medical & Biological Engineering & Computing 医学-工程:生物医学
CiteScore
6.00
自引率
3.10%
发文量
249
审稿时长
3.5 months
期刊介绍: Founded in 1963, Medical & Biological Engineering & Computing (MBEC) continues to serve the biomedical engineering community, covering the entire spectrum of biomedical and clinical engineering. The journal presents exciting and vital experimental and theoretical developments in biomedical science and technology, and reports on advances in computer-based methodologies in these multidisciplinary subjects. The journal also incorporates new and evolving technologies including cellular engineering and molecular imaging. MBEC publishes original research articles as well as reviews and technical notes. Its Rapid Communications category focuses on material of immediate value to the readership, while the Controversies section provides a forum to exchange views on selected issues, stimulating a vigorous and informed debate in this exciting and high profile field. MBEC is an official journal of the International Federation of Medical and Biological Engineering (IFMBE).
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