早发 Luminal A 型乳腺癌发病率的增加与酗酒模式有关。

IF 7.4 1区 医学 Q1 Medicine
Jianjiu Chen, Rebecca Kehm, Wan Yang, Mary Beth Terry
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引用次数: 0

摘要

背景:在美国,年轻女性患乳腺癌(BC)的比例一直在上升。酒精是乳腺癌的一个既定风险因素,并且一直与激素受体阳性癌症相关,而这种类型的乳腺癌在年轻女性中增长最快。鉴于这些趋势,我们开展了一项生态学研究,利用监测、流行病学和最终结果(SEER)癌症登记处的乳腺癌数据,研究酒精消费,特别是酗酒趋势,是否与 40 岁以下确诊的女性乳腺癌相关。我们通过使用结果发生前 10 年的接触情况(滞后模型)来考虑癌症诊断前的潜伏期;我们还对 10 年的总接触情况进行了单独的累积分析:中度(发病率比 (IRR) = 1.05,95% 置信区间 (CI) = 1.02-1.07)和重度(发病率比 (IRR) = 1.05,95% 置信区间 (CI) = 1.02-1.07)(分别为≥1杯和≥2杯/天)饮酒均与A型乳腺癌有关,但与其他分子亚型无关。在10年滞后模型(IRR = 1.06,95% CI = 1.02-1.11)和累积模型(IRR = 1.05,95% CI = 1.02-1.07)中,酗酒与早发Luminal A型乳腺癌发病率增加有关。在累积模型中,酗酒也与早发Luminal B BC相关(IRR = 1.04,95% CI = 1.01-1.07),但在任一模型中,酗酒都与ERBB2富集或三阴性早发BC无关:这些趋势支持这样的假设,即早发乳腺癌增加的原因之一是酒精摄入量增加,包括暴饮。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Increasing rates of early-onset Luminal A breast cancers correlate with binge drinking patterns.

Background: Breast cancer (BC) rates have been increasing in young women in the U.S. Alcohol is an established risk factor for breast cancer and has been consistently associated with hormone receptor positive cancers, the type of breast cancer that has been increasing the fastest in young women. Given these trends, we conducted an ecological study to examine whether alcohol consumption, and specifically binge drinking trends, were correlated with female breast cancer diagnosed under 40 years of age using breast cancer data from the Surveillance, Epidemiology, and End Results (SEER) Cancer Registry. We accounted for a latent period before cancer diagnosis by using exposure 10 years before the outcome (lag model); we also conducted a separate cumulative analysis of 10-year aggregate exposure.

Findings: Moderate (Incidence Rate Ratio (IRR) = 1.05, 95% Confidence Interval (CI) = 1.02-1.07) and heavy (IRR = 1.05, 95% CI = 1.02-1.07)(≥ 1 and ≥ 2 drinks/day, respectively) alcohol consumption were each associated with Luminal A breast cancer but not the other molecular subtypes. Binge drinking was associated with an increased rate of early-onset Luminal A BC in both the 10-year lag model (IRR = 1.06, 95% CI = 1.02 to 1.11) and the cumulative model (IRR = 1.05, 95% CI = 1.02-1.07). Binge drinking was also associated with early-onset Luminal B BC in the cumulative model (IRR = 1.04, 95% CI = 1.01-1.07), but not associated with ERBB2-enriched or triple negative early-onset BC in either model.

Conclusion: These trends support the hypothesis that one reason for the increase in early-onset breast cancer is from increased alcohol intake including binge drinking.

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来源期刊
CiteScore
12.00
自引率
0.00%
发文量
76
审稿时长
12 weeks
期刊介绍: Breast Cancer Research, an international, peer-reviewed online journal, publishes original research, reviews, editorials, and reports. It features open-access research articles of exceptional interest across all areas of biology and medicine relevant to breast cancer. This includes normal mammary gland biology, with a special emphasis on the genetic, biochemical, and cellular basis of breast cancer. In addition to basic research, the journal covers preclinical, translational, and clinical studies with a biological basis, including Phase I and Phase II trials.
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