使用 VirScan 进行全面的噬菌体展示病毒抗体分析：在慢性免疫介导疾病中的潜在应用。

IF 4 2区医学 Q2 VIROLOGY

Journal of Virology Pub Date : 2024-11-19 Epub Date: 2024-10-21 DOI:10.1128/jvi.01102-24

Jed Valentiner Shrewsbury, Evangelin Shaloom Vitus, Adam Leslie Koziol, Anna Nenarokova, Tine Jess, Rahma Elmahdi

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引用次数: 0

摘要

噬菌体免疫沉淀测序（PhIP-Seq）是一种利用可编程噬菌体展示进行血清学研究的高通量平台。VirScan是一种特定的PhIP-Seq文库，编码来自所有已知人类病毒的病毒肽，可对过去的病毒暴露进行全面量化。我们回顾了它在免疫介导疾病 (IMD) 中的应用，强调了它在 IMD 发展过程中识别病毒暴露的实用性。最后，我们通过将其与其他大规模全息数据集整合，评估了它在精准医疗方面的潜力。

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Comprehensive phage display viral antibody profiling using VirScan: potential applications in chronic immune-mediated disease.

Phage immunoprecipitation sequencing (PhIP-Seq) is a high-throughput platform that uses programmable phage display for serology. VirScan, a specific PhIP-Seq library encoding viral peptides from all known human viruses, enables comprehensive quantification of past viral exposures. We review its use in immune-mediated diseases (IMDs), highlighting its utility in identifying viral exposures in the context of IMD development. Finally, we evaluate its potential for precision medicine by integrating it with other large-scale omics data sets.

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来源期刊

Journal of Virology 医学-病毒学

CiteScore

10.10

自引率

7.40%

发文量

906

审稿时长

1 months

期刊介绍： Journal of Virology (JVI) explores the nature of the viruses of animals, archaea, bacteria, fungi, plants, and protozoa. We welcome papers on virion structure and assembly, viral genome replication and regulation of gene expression, genetic diversity and evolution, virus-cell interactions, cellular responses to infection, transformation and oncogenesis, gene delivery, viral pathogenesis and immunity, and vaccines and antiviral agents.