地球防护罩之外抗氧化剂为通往火星铺平道路的惊人方式。

IF 4.2 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Neurochemistry Pub Date : 2024-10-10 DOI:10.1111/jnc.16233

Miguel Skirzewski, Aureliano Skirzewski

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引用次数: 0

摘要

星际旅行因银河宇宙辐射（GCR）而带来严重风险。Sanghee 等人最近的一项研究发现，暴露在 33 波束 GCR 模拟器中的雌性小鼠会出现长期认知障碍，这凸显了宇航员面临的持续风险。该研究使用了与人类认知测试类似的触摸屏任务，增强了其与太空任务的相关性。此外，抗氧化/抗炎化合物 CDDO-EA 显示出缓解这些认知缺陷的潜力。这项研究在提供有关 GCR 影响的重要见解的同时，还强调了进一步研究保护策略（包括饮食干预）的必要性，以确保宇航员在地球保护罩之外执行长期任务时的安全。

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Beyond Earth's shield: The surprising way antioxidants could pave the road to Mars.

Interplanetary travel poses serious risks because of Galactic cosmic radiations (GCRs). A recent study by Sanghee et al. revealed long-term cognitive impairments in female mice exposed to a 33-beam GCR simulator, highlighting persistent risks for astronauts. The study's use of touchscreen tasks, similar to human cognitive tests, enhances its relevance for space missions. Additionally, the antioxidant/anti-inflammatory compound CDDO-EA showed potential in mitigating these cognitive deficits. While offering critical insights into GCR effects, the study emphasizes the need for further research into protective strategies, including dietary interventions, to ensure astronaut safety on extended missions beyond Earth's protective shield.

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来源期刊

Journal of Neurochemistry 医学-神经科学

CiteScore

9.30

自引率

2.10%

发文量

181

审稿时长

2.2 months

期刊介绍： Journal of Neurochemistry focuses on molecular, cellular and biochemical aspects of the nervous system, the pathogenesis of neurological disorders and the development of disease specific biomarkers. It is devoted to the prompt publication of original findings of the highest scientific priority and value that provide novel mechanistic insights, represent a clear advance over previous studies and have the potential to generate exciting future research.