红细胞去核术一览。

IF 3.3 3区 生物学 Q3 CELL BIOLOGY
Journal of cell science Pub Date : 2024-10-01 Epub Date: 2024-10-14 DOI:10.1242/jcs.261673
Lucas M Newton, Velia M Fowler, Patrick O Humbert
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引用次数: 0

摘要

红细胞去核是哺乳动物红细胞终末分化的倒数第二步,是红细胞(红血球)去除细胞核和伴随核物质的独特细胞过程。这一复杂的多阶段过程从染色质压实和细胞周期停滞开始,最后产生两个子细胞:一个是含有被排出的细胞核的肾细胞,另一个是成熟为红细胞的无核网织红细胞。虽然去核被比作不对称细胞分裂(ACD),但似乎不存在 ACD 的许多机制特征。相反,去核似乎依赖于从细胞迁移、内体运输和细胞凋亡中借鉴的机制,以及微环境中独特的细胞相互作用。在这篇《细胞科学一瞥》(Cell Science at a Glance)文章和随附的海报中,我们总结了目前对调节骨髓微环境中红细胞去核和巨噬细胞吞噬脓细胞的关键细胞内事件的形态特征和遗传驱动因素的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Erythroblast enucleation at a glance.

Erythroid enucleation, the penultimate step in mammalian erythroid terminal differentiation, is a unique cellular process by which red blood cells (erythrocytes) remove their nucleus and accompanying nuclear material. This complex, multi-stage event begins with chromatin compaction and cell cycle arrest and ends with generation of two daughter cells: a pyrenocyte, which contains the expelled nucleus, and an anucleate reticulocyte, which matures into an erythrocyte. Although enucleation has been compared to asymmetric cell division (ACD), many mechanistic hallmarks of ACD appear to be absent. Instead, enucleation appears to rely on mechanisms borrowed from cell migration, endosomal trafficking and apoptosis, as well as unique cellular interactions within the microenvironment. In this Cell Science at a Glance article and the accompanying poster, we summarise current insights into the morphological features and genetic drivers regulating the key intracellular events that culminate in erythroid enucleation and engulfment of pyrenocytes by macrophages within the bone marrow microenvironment.

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来源期刊
Journal of cell science
Journal of cell science 生物-细胞生物学
CiteScore
7.30
自引率
2.50%
发文量
393
审稿时长
1.4 months
期刊介绍: Journal of Cell Science publishes cutting-edge science, encompassing all aspects of cell biology.
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