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引用次数: 0
摘要
本研究全面综述了有关使用尿中性粒细胞明胶酶相关脂质体蛋白(uNGAL)作为儿童尿路感染(UTI)诊断工具的文献。我们进行了荟萃分析,以评估尿中性粒细胞凝胶酶在诊断UTI和区分儿童急性肾盂肾炎(APN)与其他部位感染方面的有效性。我们检索了 PubMed、Web of Science、Cochrane Library 和 EMBASE 中截至 2023 年 1 月发表的报告。我们仅纳入了使用uNGAL诊断0-18岁儿童UTI和APN的已发表文献。两位作者独立审阅了纳入的研究,并根据纳入和排除标准提取了相应的数据。采用双变量混合效应模型对每项研究的灵敏度、特异性和曲线下面积进行了汇总。共有13项研究符合本综述的纳入标准:其中 8 项报告了 uNGAL 诊断 UTI 的情况,2 项报告了 uNGAL 诊断 APN 的情况,3 项报告了 UTI 和 APN 的情况。在所有纳入的研究中,uNGAL对UTI诊断的敏感性(0.88,95% CI 0.79-0.94)和特异性(0.86,95% CI 0.78-0.92)均较好。uNGAL诊断APN的敏感性和特异性分别为0.79(95% CI 0.72-0.85)和0.78(95% CI 0.50-0.93)。然而,uNGAL 的使用在儿童 APN 诊断中仍无明显优势。因此,有必要对该检测方法进行优化和进一步探索,以提高诊断的准确性。
期刊介绍:
The Iranian Journal of Kidney Diseases (IJKD), a peer-reviewed journal in English, is the official publication of the Iranian Society of Nephrology. The aim of the IJKD is the worldwide reflection of the knowledge produced by the scientists and clinicians in nephrology. Published quarterly, the IJKD provides a new platform for advancement of the field. The journal’s objective is to serve as a focal point for debates and exchange of knowledge and experience among researchers in a global context. Original papers, case reports, and invited reviews on all aspects of the kidney diseases, hypertension, dialysis, and transplantation will be covered by the IJKD. Research on the basic science, clinical practice, and socio-economics of renal health are all welcomed by the editors of the journal.